Protein Alignment Cyp4p3 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_610473.1
• Gene: Cyp4p3 / 35948
• FlyBaseID: FBgn0033397
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 169/536 - (31%)
• Similarity: 257/536 - (47%)
• Gaps: 71/536 - (13%)

  Fly     2 LILWLVGAFIVL---IQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYG 63
            |:|.||||..:|   :.|.|.. .|.|      :|:|. ..|.|.            .|.|  :|
Human    20 LLLLLVGASWLLAHVLAWTYAF-YDNC------RRLRC-FPQPPR------------RNWF--WG 62

  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMGTAIY--------NVIDADSAERVLNDPNLI--NKGTIY 118
              |.|:...:.:..:.|.:..|.|..|..::        ::...|....|:|....|  .....|
Human    63 --HQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFY 125

  Fly   119 DFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAII 179
            .||.|:|..|||.|.|.||...|:||:|.||||||..:.:|| .||:..:    :.......|.:
Human   126 SFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIF-NESVNIMHAKWQLLASEGSACL 189

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE- 243
            .:.|.|...||:|:.:...... ....||...|.....::.....:|....||..|.|:.:..:
Human   190 DMFEHISLMTLDSLQKCVFSFD-SHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDG 253

  Fly   244 KDYASALDVVHGFSSEIIAKRRDQL-----NDEIDSRGNTQTAEDELFTSKKRFAMLDTLILA-E 302
            :.:..|..:||.|:..:|.:||..|     :|.:.::..::|.:           .:|.|:|: :
Human   254 QRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD-----------FIDVLLLSKD 307

  Fly   303 KDG--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDD-ELNILN 364
            :||  |.|. .|..|.||.||||:|||:.||.:.|.:::.:||.||:|.||:|..:.| |...:.
Human   308 EDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

  Fly   365 IGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDS 429
            ...|..|..|...:||::||.|.||.:.|..|::..|.:|.::|||....:.||..|.||..|..
Human   372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPD 436

  Fly   430 PEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE-IDPK-- 491
            ||.:.|.||.|||.:.|...|:||||||.||||||.|||.|||.::...|.:|::||: .:|:
Human   437 PEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRK 501

  Fly   492 ---TIVFQTGLTLRTK 504
               .:..:.||.||.:
Human   502 PELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	CYP4	81..509	CDD:410721	148/454 (33%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	147/454 (32%)