DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and cyp2j20

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	517	Identity:	123/517 - (23%)
Similarity:	211/517 - (40%)	Gaps:	94/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CILGFFAKRIRTKNGQN----PESIAPLVKGSTIFANSFDLYGKDHSGVFEHSRDCAKKLGKSYA 85
            |:....:..|:.|..:|    |.|: |::.         |::..|.|.:.....:.|:|.||.::
Zfish    20 CVFLLLSDFIKNKTPKNFPPGPWSL-PIIG---------DIHHIDPSKLHLQLSEFAEKYGKIFS 74

  Fly    86 EYAMGTAIYNVIDADSAERVLNDPNLINK-----------GTIYDFLHPFL-RTGLLTSTGKKWH 138
            ....|..|.          |||..||:.:           ..|....|..: ..||:.|:|.||.
Zfish    75 LRLFGPRIV----------VLNGYNLVKEVYTQEGDNLADRAILPLFHDIIGDKGLVASSGYKWK 129

  Fly   139 ARRKM-LSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAIISLNEVIPRFTLNS-----ICETA 197
            .:|:. ||...:|.:..:..|..|.....||.:...|::.    ....||..||:     ||...
Zfish   130 QQRRFALSTLRNFGLGKKNLEPSINLESGFLNEAISNEQG----QPFDPRLLLNNAVSNVICALV 190

  Fly   198 MGVKLDEMAEKGDRYRENFRQ---IEECFIRRMSNPLLWSDTLFKMF--AEKDYASALDVVHGFS 257
            .|.:.|....|.....:|..:   :|.....::.|.|.|   |.::.  ..|...:....:..|.
Zfish   191 FGNRFDYSDHKFQTLLKNINETVHLEGGICAQLYNMLPW---LMRLLPGPHKRIIALWGKLIEFV 252

  Fly   258 SEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFE 322
            .|.:.:.:.. :|.::.|.......||:...|.     ||  .|..|  ::::.|| .:| |...
Zfish   253 GEKVNEHKVD-HDPLNPRDYIDCFLDEMEKHKD-----DT--AAGFD--VENLCIC-TLD-LFVA 305

  Fly   323 GYDTTSIGLMFGLMNMSLYPEEQEKCYQEI--------QANIDDELNILNIGQLNKLKNLEY--- 376
            |.:|||..|.:||:.|..|||.|.|..|||        |.::.|.            .|:.|
Zfish   306 GTETTSTTLYWGLLYMMKYPEIQAKVQQEIDVIVGGSRQPSVSDR------------DNMPYTNA 358

  Fly   377 FIKETMRLFPSVPA-MGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLP 440
            .|.|..|:...:|. :.|.|:.:|::.. ..:|||:.:..::..:..:...|::|..|.|..||.
Zfish   359 VIHEIQRMGNIIPINLARTTSEDTQIEK-YSIPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLD 422

  Fly   441 ENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE--IDPKTIVFQTGLT 500
            ...:.|...|::|||.|:|.|:|::.|..|:.....:||::|...|.  ::| ::.:..|.|
Zfish   423 AEGKFRRRDAFLPFSLGKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEP-SLDYNLGAT 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	116/484 (24%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	119/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010