DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	534	Identity:	163/534 - (30%)
Similarity:	248/534 - (46%)	Gaps:	61/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDH 66
            |:|.|.||..:|   .|.|...|   |.|...:|.:....|.      |.:.|..         |
Mouse    20 LLLLLAGASCLL---AYILTPIY---GVFENSLRLRCFPQPP------KRNWILG---------H 63

  Fly    67 SGVFEHSRDCAKKLGKSYAEYAMGT-------------AIYNVIDADSAERVLNDPNLI-NKGTI 117
            .|:.:.|.:     |..|.:..:.|             .:..:......:.|:..|.|: .|.|:
Mouse    64 LGLIQSSEE-----GLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTV 123

  Fly   118 -YDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEA 177
             |.||.|:|..|||.|||.||...|:||:|.||||||..:.::| .:|...:    ::......|
Mouse   124 FYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVF-NDSTNIMHAKWQRLASKGSA 187

  Fly   178 IISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFA 242
            .:::.|.|...||:|:.:...... ....||...|.....::.....||....||..|..:.:..
Mouse   188 YLNMFEHISLMTLDSLQKCVFSFD-SNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTH 251

  Fly   243 E-KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKD-- 304
            : ..:..|..:||.|:..:|.:||..|.|:    |.....:.:  ...|....:|.|:|::.:
Mouse   252 DGMRFRKACRLVHDFTDAVIRERRRTLLDQ----GGVDVLKAK--AKAKTLDFIDVLLLSKDEHG 310

  Fly   305 -GLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI-DDELNILNIGQ 367
             .|.|. .|..|.||.||.|:|||:.||.:.|.|::.:||.||:|.||::..: |.|...:....
Mouse   311 KALSDE-DIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDD 374

  Fly   368 LNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEE 432
            |.:|..|...|||::||.|.|.|:.|..|::..|.:|.::|||....:.:|..|.||..|..||.
Mouse   375 LAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEV 439

  Fly   433 FRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQT 497
            :.|.||..:|.:.|...|:||||||.||||||.|||.|||..:...|.:|::||  |.|....:.
Mouse   440 YDPFRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLP--DDKEPRRKP 502

  Fly   498 GLTLRTKNQIHVKL 511
            .|.||.:..:.:|:
Mouse   503 ELILRAEGGLWLKV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	148/474 (31%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	150/494 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850