DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	544	Identity:	138/544 - (25%)
Similarity:	246/544 - (45%)	Gaps:	108/544 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDHSGV 69
            |::.|..:::.:||         |..:.::..|.|....:..|.: |:.:|      |.:   |:
Human    12 WVLVATSLVLLYIY---------GTHSHKLFKKLGIPGPTPLPFL-GTILF------YLR---GL 57

  Fly    70 FEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVL---------NDPNLINKGTIYDFLHPFL 125
            :...|:|.:|.|:.:..|.....:..::|.|..:.||         |...|...|        ||
Human    58 WNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG--------FL 114

  Fly   126 RTGLLTSTGKKWHARRKMLSPTF---HFN----ILNQFQEIFITESLKFLEQFKGNDEAIISLNE 183
            ::.|..:..::|...|.:|||.|   .|.    |::|..::.:    :.|.|...|.:: |:|.:
Human   115 KSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV----RSLRQEAENSKS-INLKD 174

  Fly   184 VIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEEC-FIRRMSNPLLWSDTLFKMFAEKDYA 247
            ....:|::.|..|..||.||.:....|.:.:|.:::.:. |:    :|.|...:||........|
Human   175 FFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL----DPFLLLISLFPFLTPVFEA 235

  Fly   248 SAL-----DVVHGFSSEIIAKRRDQLNDE-----------IDSRGNTQTAEDELFTSKKRFAMLD 296
            ..:     ||.|...:.|...:..:|.|:           |||:.:.:|        |...|:.|
Human   236 LNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKET--------KSHKALSD 292

  Fly   297 TLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELN 361
            ..::|:  .:|           ::|..|||||..|.|.:..::.:|:.|:|..:||.|.:.::..
Human   293 LELVAQ--SII-----------IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP 344

  Fly   362 ILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEY 426
            : ....|.:::.|:..:.||:||||.|..:.|...::.|: ||:.:|||..:.|.::.:|.:|:|
Human   345 V-TYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKY 407

  Fly   427 WDSPEEFRPE-RFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQI------ 484
            |..||:|.|| ||..:|..:...|.||||.||.|||||.:||:..:|..::..|:.|..
Human   408 WTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKET 472

  Fly   485 --------LPEIDP-KTIVFQTGL 499
                    ||.:.| |.||.:..|
Human   473 QIPLKLDNLPILQPEKPIVLKVHL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	129/495 (26%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	130/504 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910