DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	538	Identity:	167/538 - (31%)
Similarity:	257/538 - (47%)	Gaps:	70/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIL---WLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLY 62
            :|:|   |::..  :||| ||...|:|..|..|.        |.|       |.:.:..
Mouse    22 LLLLGASWILAR--ILIQ-IYAAYRNYRHLHGFP--------QPP-------KRNWLMG------ 62

  Fly    63 GKDHSGVFEHSRDCAKKLGKSYAEYAMG--------TAIYNVIDADSAERVLNDPNLIN-KGTI- 117
               |.|:...:....|:|.:....|..|        ..:..:..:|....:||....:. |..|
Mouse    63 ---HVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIF 124

  Fly   118 YDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAI 178
            |..|.|:|..|||.|.|.||...|:||:|.||||||..:.:|| .:|...:    ::...:..|.
Mouse   125 YSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIF-NDSTNIMHAKWQRLISDGSAR 188

  Fly   179 ISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE 243
            :.:.|.:...||:|:.:...... ....||...|.....::.....:|...||::.|.|:.:..:
Mouse   189 LDMFEHVSLMTLDSLQKCVFSFD-SNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPD 252

  Fly   244 -KDYASALDVVHGFSSEIIAKRR----DQ-LNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILA- 301
             ..:..|.:|||.|:..:|.:|.    || |:|.:.|:..::|.:           .:|.|:|:
Mouse   253 GMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD-----------FIDVLLLSK 306

  Fly   302 EKDG--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI-DDELNIL 363
            ::||  |.|. .|..|.||.||||:|||:.||.:.|.|::.:||.||:|.||:|..: ..|...:
Mouse   307 DEDGKELSDE-DIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEI 370

  Fly   364 NIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWD 428
            ....|.:|..|...|||::||.|.|..:.|..|::..|.:|..:|||....:.:|.||.||..|.
Mouse   371 EWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWP 435

  Fly   429 SPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTI 493
            .||.:.|.||.|||.::....|:||||||.||||||.|||.|||..:...|.:|::||  |.|..
Mouse   436 DPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLP--DDKEP 498

  Fly   494 VFQTGLTLRTKNQIHVKL 511
            ..|..|.||.:..:.:::
Mouse   499 RRQPELILRAEGGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	152/474 (32%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	155/498 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850