DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	521	Identity:	162/521 - (31%)
Similarity:	246/521 - (47%)	Gaps:	68/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GQNPESIAP-----LVKGSTIFAN----SFDLYGK-----------------DHSGVFEHSRDCA 77
            |..|.:.:|     ||.||.:.|.    ::..|..                 .|.|:...:.:..
Human    10 GLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM 74

  Fly    78 KKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGT------------IYDFLHPFLRTGLL 130
            |.|.:....|..|..::  :.......:|..|::|...|            .|.||.|:|..|||
Human    75 KTLTQLVTTYPQGFKLW--LGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLL 137

  Fly   131 TSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAIISLNEVIPRFTLN 191
            .|.|.||...|:||:|.||||||..:.:|| .:|:..:    ::......|.:.:.|.|...||:
Human   138 LSGGDKWSRHRRMLTPAFHFNILKPYMKIF-NKSVNIMHDKWQRLASEGSARLDMFEHISLMTLD 201

  Fly   192 SICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE-KDYASALDVVHG 255
            |:.:.....: ....||...|.....::.....:|....||.:|.|:.:..: :.:..|..:||.
Human   202 SLQKCVFSFE-SNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHD 265

  Fly   256 FSSEIIAKRRDQLNDEIDSRGNTQTAEDEL--FTSKKRFAMLDTLILA-EKDG--LIDHIGICEE 315
            |:..:|.:||..|        .||..:|.|  ....|....:|.|:|: ::||  |.|. .|..|
Human   266 FTDAVIQERRCTL--------PTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDE-DIRAE 321

  Fly   316 VDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNI-LNIGQLNKLKNLEYFIK 379
            .||.||||:|||:.||.:.|.:::.:||.||:|.||:|..:.|...| :....|.:|..|...||
Human   322 ADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIK 386

  Fly   380 ETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQ 444
            |::||.|.||.:.|..|::..|.:|.::|||....:::..||.||..|..||.:.|.||..||.:
Human   387 ESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIK 451

  Fly   445 NRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILP-EIDPK-----TIVFQTGLTLRT 503
            .|...|:||||||.||||||.|||.|||.::...|..|:||| ..:|:     .:..:.||.||.
Human   452 ERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRV 516

  Fly   504 K 504
            :
Human   517 E 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	155/501 (31%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	149/466 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850