DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	428	Identity:	169/428 - (39%)
Similarity:	244/428 - (57%)	Gaps:	26/428 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ADSAERVLNDPNLINKGTIYDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITE 163
            |::.|.|||:|..|:|...|.||||:|.||||||||.||..|||||:|||||:||.:|.|:...:
Zfish    97 AETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSILTEFLEVMNEQ 161

  Fly   164 SLKFLEQF-KGNDEAIISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRM 227
            :...:|:. |...:...:....|....|:.|||||||.::...:.....|.....::.:...||.
Zfish   162 AEVLIEKLEKQAGKGPFNCFSHITLCALDIICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQ 226

  Fly   228 SNPLLWSDTLFKMFAE-KDYASALDVVHGFSSEIIAKRRDQLN-DEIDSRGNTQTAEDELFTSKK 290
            ..|..|.|.::....| :::..:|.::|.|:..:|.:|.:.|: .|.||..:.        ..:|
Zfish   227 RMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAEYLSYVESDSESDQ--------GMRK 283

  Fly   291 RFAMLDTLI-LAEKDG-LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQ 353
            |.|.||.|: ..::|| ::.|..|.|||||.||||:|||:..:.:.:..:..:||.|.|..||:.
Zfish   284 RRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELF 348

  Fly   354 ANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVF 418
            ....:....:|...|.||:.||..|||::|||||||...|....:|:: ||..:|||:.|.|..:
Zfish   349 EVFGESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQI-NGFKVPKGTNIVVITY 412

  Fly   419 DIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQ 483
            .:||:|.::..|||||||||||||...||.|||||||||.||||||:||:.|.|.::..:|:.|.
Zfish   413 ALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFN 477

  Fly   484 IL-----PEIDPKTIVFQTG-LTLRTKNQIHVKLVRRK 515
            |:     .|:.|      .| |.||.:..|.:.|.|||
Zfish   478 IVACQKREELRP------LGELVLRPEQGIWITLERRK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	164/416 (39%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	164/418 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950