DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	560	Identity:	142/560 - (25%)
Similarity:	233/560 - (41%)	Gaps:	112/560 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVGAFIVLIQWIYRLNRDYCILG-----FFAKRIRTKNGQNPESIAPLVKGSTIFANSFDL 61
            |:.:|....::...|.:|..:...|.|     ||...:|.|:|                .:.||:
Zfish    10 LLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDG----------------FHVFDM 58

  Fly    62 YGKDHSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVL---------NDPNLINKGTI 117
                         ||.:|.|:.:..|.....:..::|....:.||         |..|....|.:
Zfish    59 -------------DCFEKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGAL 110

  Fly   118 YDFLHPFLRTGLLTSTGKKWHARRKMLSPTF-------HFNILNQFQEIFITESLKFLEQFKGND 175
            ||        .:..:....|...|.:|||:|       .|.|:.:...|.:....|..::.:..|
Zfish   111 YD--------AVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESAD 167

  Fly   176 EAIISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKM 240
                 :.|....::::.:..||..|.:|.:....|.:..|.:::.:.   .:.|||......|..
Zfish   168 -----IKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKF---DLLNPLFLLIAFFPF 224

  Fly   241 FA---EK-DYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQT-AEDELFTSKKRFAMLDTLIL 300
            .|   || |:|.....|..|....:.|        |.|..:|:| |:|   .:|||...|..::.
Zfish   225 MAPVLEKMDFALFPTSVTDFFYAALQK--------IKSDRDTKTVAKD---NTKKRVDFLQLMVD 278

  Fly   301 AE------------KDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEI- 352
            ::            :.||.|| .|..:....:|.||:|:|..|.|...|::..||..:|..:||
Zfish   279 SQTGVKHKSDGEHTEKGLSDH-EILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEID 342

  Fly   353 -----QANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQ 412
                 ||.:|.|       .|..:..|:..:.|::||||....:.|...:..|: |||::||...
Zfish   343 ETFPNQAPVDYE-------TLMSMDYLDAALSESLRLFPVAARLERVCKKTVEI-NGLLIPKDLV 399

  Fly   413 IFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVA 477
            :.|..:.:||:|:||..||.|:||||...|.::...|.|:||..|.|||||.:||...||..:|.
Zfish   400 VMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVE 464

  Fly   478 LLKQFQILPEIDPKTIVFQTGLT--LRTKNQIHVKLVRRK 515
            :|::|.: ...|...:..:.|..  |..|:.|.:||..||
Zfish   465 ILQRFDV-SVCDETQVPLELGFNGLLSPKDPIKLKLQPRK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	125/491 (25%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	133/529 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000