DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p3 and Cyp313b1

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	128/546 - (23%)
Similarity:	251/546 - (45%)	Gaps:	89/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLVGAFIVLIQWIYRL---NRDYCILGFFAKRIRTKNG----------QNPESIAPLVKG-STIF 55
            ||      |:.|:|.|   .|.|.:    |.::|...|          .|||:....:.| |..|
  Fly    10 WL------LLAWLYFLWSRRRYYKV----AWQLRGPIGWPLIGMGLQMMNPETFLQYMDGLSRQF 64

  Fly    56 ANSFDLYGKDHSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVI-DADSAERVLNDPNLINKGTIYD 119
            ...|..:                          |||:.:..| |..|.|::||..:..|||..|.
  Fly    65 KAPFISW--------------------------MGTSCFLYINDPHSVEQILNSTHCTNKGDFYR 103

  Fly   120 FLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAI-----I 179
            |:...:..||.||:..:||..|::::|.|...||:.|..||..|:...|::.:  .|.:     :
  Fly   104 FMSSAIGDGLFTSSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLE--LEGVQHGKRL 166

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFK---MF 241
            .:.:::.:..|.:.|:|.||.|::...:......:.:..:.|..::||.:|.|:.|.:::   :|
  Fly   167 EIYQILKKIVLEAACQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLF 231

  Fly   242 AEKDYASALDVVHGFSSEIIA---------KRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDT 297
            ..:.  ..:.::.||..:::.         ...||...|::.||.::.    :|..:.|..:
  Fly   232 RLQQ--KVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKA----IFIEQVREHV--- 287

  Fly   298 LILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNI 362
                 :.|.:....:.:|.:..:...::|||..|.|.::.::::|..|||.::|:...:....:|
  Fly   288 -----ERGQLSWQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDI 347

  Fly   363 LNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNG---LILPKGSQIFVHVFDIHRNP 424
             |:.||.:|:..|..|.|.||||..||.:.|...::.:|..|   .::|:|:||.:.::::.|:.
  Fly   348 -NLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDE 411

  Fly   425 EYWDS-PEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEI 488
            ..|.. ...:.|:.....:|..||.:|::||:.|.|.|||.::|...||.|:..:.:.::|..|.
  Fly   412 RVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEA 476

  Fly   489 DPKTIVFQTGLTLRTKNQIHVKLVRR 514
            ..:.::.:..::|:.|:....::.||
  Fly   477 RLEELLVKGNISLKLKDYPLCRVERR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	109/472 (23%)
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	114/483 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	5.970