DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p3 and cyp46a1.2

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_009292815.1	Gene:	cyp46a1.2 / 393433	ZFINID:	ZDB-GENE-040426-1184	Length:	501	Species:	Danio rerio

Alignment Length:	543	Identity:	131/543 - (24%)
Similarity:	232/543 - (42%)	Gaps:	95/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVG----AFIVLIQWIYRLNRDY-CILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDL 61
            :|.:|:.    ||:....:|:.|::.| .|.|  ..|.....|.:|.....:....::..:.|..
Zfish     9 IIFYLLSAVFTAFLAYCLYIHHLHQKYDHIPG--PPRDNFLLGHSPSLTKAMYSDDSLIHDLFLQ 71

  Fly    62 YGKDHSGVFE-----------HSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKG 115
            :.:.:..|:.           |..:..|.:..| .:||.        |..|..|:.   ||..|
Zfish    72 WAEKYGPVYRINTLHYIAILVHCPEATKTILMS-PKYAK--------DPFSYSRLF---NLFGK- 123

  Fly   116 TIYDFLHPFLRTGLLTSTGKK-WHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFK--GNDEA 177
                   .||..||:|:.... |:.:|:::.|.|..:.|......|...|.:.:::.:  .|::.
Zfish   124 -------RFLGNGLVTAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKT 181

  Fly   178 IISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFA 242
            ...:::::...||:.||:.|.||.|:.:.:|...::   ..||.| :..|:  |...|.||::|.
Zfish   182 PAVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSPFQ---NAIELC-LNGMA--LDARDPLFRIFP 240

  Fly   243 E-----KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQT-----AEDELFTSKKRF-AMLD 296
            :     :....|..::.....:.|..|:..:.:..|...:..|     ||:|...|.:.. .|:|
Zfish   241 KNWKLIQQIRDAAVLLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKIAEEENVNSSEDLEQMMD 305

  Fly   297 TLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELN 361
            ..:                  |....|.:||:..|.|.:|.:...||    .|:..:|.:|:.|.
Zfish   306 NFV------------------TFFIAGQETTANQLSFAIMALGRNPE----IYKRAKAEVDEVLG 348

  Fly   362 I---LNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRN 423
            .   ::...|.||..|...:|||:||:|:.|...| ...|..:.||:.:|.|..:....|...|.
Zfish   349 TKREISNEDLGKLTYLSQVLKETLRLYPTAPGTNR-WLHEDMIINGIKIPGGCSVMFSSFVSQRL 412

  Fly   424 PEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQ--ILP 486
            .:::..|.:|.|||| .||:...: |.|.||:.|.|.|:||.|:..|.|.::..||::|:  ::|
Zfish   413 EKFFKDPLKFDPERF-DENAPKPY-YCYYPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFSLVP 475

  Fly   487 --EIDPKTIVFQTGLTLRTKNQI 507
              ..|.|    .|| |||.|:.:
Zfish   476 GQSFDIK----DTG-TLRPKSGV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	118/482 (24%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	123/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910