DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp316a1

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	125/534 - (23%)
Similarity:	226/534 - (42%)	Gaps:	102/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YCILGFF----AKRIRT--KNGQNPESIAPLVKGSTIFANSFDLYGKDHS-------GVFEHSRD 75
            :|:...|    |:|.|:  ||.:.|              .::.|.|..|.       ..|:.|.:
  Fly    10 FCLASAFNYFRARRQRSLIKNLKGP--------------FTWPLMGAMHKLLFLTPINFFQRSTE 60

  Fly    76 CAKKLGKSYAEYAMGTAIYNVIDADSAERVL-NDPNLINKGTIYDFLHPFLRTGLLTSTGKKWHA 139
            ...|.|.....:........:.|.:.:.::| ||.:|   .|.|:.:..:|..|:|....::|..
  Fly    61 YLTKYGTFSRCWVFHRLFIPLADLELSRQLLENDTHL---ETGYELMKDWLVGGVLMCQSEQWQK 122

  Fly   140 RRKMLSPTFHFNILNQFQEIFITESLKFLEQF-KGNDEAIISLNEVIPRFTLNSICETAMGVKLD 203
            |..::|..|....|.|..::...::.:.|::. |..|:.:..:...:....|:.:..|..|.|..
  Fly   123 RHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQADQKVFDIWYTVSPIVLDLMVMTTCGAKPS 187

  Fly   204 EMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAEKDYASALDVVHGFSSEIIAKRRD-- 266
            |      .|.:|.:.:.|.:.:|..:  |.|...|.              :..||..:.||::
  Fly   188 E------EYSKNLKDLSEIYRKRFLS--LQSANRFN--------------YWLSSPFMRKRQNRL 230

  Fly   267 --QLNDEIDSRGNTQTAEDEL-------------FTSKKRFAMLDTLILAEKDGLIDHIGICEEV 316
              :||||.::......::::|             ...|...::|: ::|..||..:....||.|:
  Fly   231 IKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLE-ILLESKDPQLTGEEICGEL 294

  Fly   317 DTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNI----GQLNKLKNLEYF 377
            :|..:.||...|..|.|.|:.::..|..|:||.        ||||:..|    ..|.||..|:..
  Fly   295 NTCNYLGYQLCSPALCFCLVTIARNPSVQQKCL--------DELNLAQIKDQGWDLEKLNYLDAV 351

  Fly   378 IKETMRLFPSVPAMGRETTRETELSNGLI----LPKGSQIFVHVFDIHRNPEYWDSPEEFRPERF 438
            :.|||||:|....:||:..::...::.::    ||.||:|:::::::.||...:.....|..:||
  Fly   352 LHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRF 416

  Fly   439 L---PENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLT 500
            |   ||         .:.:|.|.|.|..:||:||.:|||:..:|..|::||..|  .:.....|.
  Fly   417 LDSPPE---------LLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGD--EVRLDLRLV 470

  Fly   501 LRTKNQIHVKLVRR 514
            |.:.|...:.|..|
  Fly   471 LGSSNGFQLALKPR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	114/487 (23%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	113/491 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070