DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4ac2

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	230/510 - (45%)
Similarity:	328/510 - (64%)	Gaps:	18/510 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LIQWIYR-----LNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDHSGVFEH 72
            |:.:|:|     |||.|.||. ..|||||::|...||...:....|.|.|:|||.......:|..
  Fly    11 LVIFIFRKLWAHLNRTYFILS-LCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNF 74

  Fly    73 SRDC-AKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTGLLTSTGKK 136
            .||. ||..|::|..|.....:||::.|:.||.:|....||.|..||:.|.|||..|||.||.:|
  Fly    75 MRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQK 139

  Fly   137 WHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAIISLNEVIPRFTLNSICETAMGVK 201
            ||:|||.|:|.|||.:|..|..||..|..|.::....:....:.||:|||:||||::||||:|||
  Fly   140 WHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNMELELNQVIPQFTLNNVCETALGVK 204

  Fly   202 LDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE-KDYASALDVVHGFSSEIIAKRR 265
            ||:::| |.|||::...|||...:|:.||..::...|.:|.: :...:.|.:.|.|||.||.|||
  Fly   205 LDDLSE-GIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRR 268

  Fly   266 DQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIG 330
            ...      :.|....||| |..|:|:||||||:.||.||.|||.|||:||:|.|||||||||..
  Fly   269 SLF------KSNQLGQEDE-FGKKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMFEGYDTTSTC 326

  Fly   331 LMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRET 395
            |:|.|:.::|:.:.|:|||:||: .:.|:.:.:::.|.|:|..:|..|||::|||||||.:||..
  Fly   327 LIFTLLMLALHEDVQKKCYEEIK-YLPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRC 390

  Fly   396 TRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRN 460
            ..| .:.||||:||.:||.:|:::|.|:..::.:|:.|:|:||.|||:.|||.:|::||||||||
  Fly   391 VEE-GVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRN 454

  Fly   461 CIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVKLVRRK 515
            |||||||:.|:|.|:.|:::.|:|||......:.|:.|:.||||..|.||||.|:
  Fly   455 CIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIKVKLVHRE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	205/452 (45%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	208/457 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472670
Domainoid	1	1.000	382	1.000	Domainoid score	I2373
eggNOG	1	0.900	-	-		E33208_3BNNU
Homologene	1	1.000	-	-		H119658
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.900