DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p3 and Cyp318a1

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	134/571 - (23%)
Similarity:	248/571 - (43%)	Gaps:	121/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVGAFI-VLIQW--------IYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFAN 57
            :.||..||.: ||:.|        |::||      |:        .|...:.:..|:....:..|
  Fly     5 IALWACGALLAVLLAWQQRKCWRLIWQLN------GW--------RGVIQQPVLWLLLCINLHPN 55

  Fly    58 SFDLYGKDHSGVFEHSRDCAKKLGKSYAEY------AMGTAIYNVIDADSA--ERVLNDPNLINK 114
            |.                 .:|:.:....:      .:||.:...|| |.|  |.|||.|..::|
  Fly    56 SI-----------------LEKVSQYRVHFQRPLAVLVGTRVLLYID-DPAGMECVLNAPECLDK 102

  Fly   115 GTIYDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFK------G 173
            ..:.|..  |:|.|||.:.|:||..|||.|:|.|..||:..|.::|.:...:.:|||:      |
  Fly   103 TFLQDGF--FVRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHG 165

  Fly   174 NDEAIISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIR------------R 226
            ......:..:::.|..|...|.|.||..            .||.|:::..|.            |
  Fly   166 QAVKFTAAEDLLSRAVLEVSCLTIMGTP------------TNFTQLDDAHIAHSYKRLLEISAVR 218

  Fly   227 MSNPLLWSDTLFKMFAEKDYASAL-------DVVHGFSSEIIAKRRD-QLNDEIDSRGNTQTAED 283
            :..|.|....|.::.|.:.|..:.       |.|.|.   :..|.|: :|.|.:   |..::.||
  Fly   219 VVKPWLQIRLLHRLLAPELYEESKKCAKLLEDFVGGI---VRTKHRNWRLRDAV---GGEKSGED 277

  Fly   284 ELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEE-QEK 347
            .....::|. .::.:.....:|.:....|.:|..:::...::|.|..:|..|:.::....: |.:
  Fly   278 ASNGWQRRI-FIEQIFQLAANGEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRR 341

  Fly   348 CYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELS---NGLILPK 409
            ...||:|.:.| :..:.:.||.:|:.|:.|:.|::||..:||...|..:|:..|:   :..|:|:
  Fly   342 LLAEIRALVPD-VGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQ 405

  Fly   410 GSQIFVHVFDIHRNPEYWD-SPEEFRPERFLPENSQ-------------------NRHTYAYIPF 454
            .|.:.:..|::.|:..:|. :..:|.|:|||.:..:                   .||:|:::||
  Fly   406 NSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPF 470

  Fly   455 SAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKN 505
            |.|.|:|||:::.:..||..:|.|:..|....:.:.:.:.|...::|:.||
  Fly   471 SNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSDFELEKLQFVENISLKFKN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	119/508 (23%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	118/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I1605
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970