DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	148/464 - (31%)
Similarity:	234/464 - (50%)	Gaps:	36/464 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HSGVFEHSRD---CAKKLGKSYAEYA---MGTAI--YNVIDADSAERVLNDPNLI--NKGTIYDF 120
            |.|..:.:.:   ...::|:::.:..   :|..|  ..::|......:|..|.|:  ...|...|
  Rat    63 HLGTIQSNEEGMRLVTEMGQTFRDIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRF 127

  Fly   121 LHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQ------FKGNDEAII 179
            |.|:|..||..|:|.||...|::|:|.|||:||..:.:|| .:|:..:..      .:|:  |.:
  Rat   128 LKPWLGDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIF-NQSVNIMHAKWKHLCLEGS--ARL 189

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE- 243
            .:.|.|...||:|:.:...|.. ....|....|.....::....|:|.....|:.|.|:...|:
  Rat   190 EMFENISLMTLDSLQKCLFGFD-SNCQESPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTADG 253

  Fly   244 KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKD---G 305
            :.:..|.|:||.|:..:|.:||..|:    |:|..:..|.:..:..|....:|.|:||:.:   .
  Rat   254 RRFRKACDLVHNFTDAVIRERRRLLS----SQGTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKE 314

  Fly   306 LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI-DDELNILNIGQLN 369
            |.|. .|..|.||.||.|:|||:..|.:.|.|::.:||.||:|.||:...: |.|...:....|.
  Rat   315 LSDE-DIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLA 378

  Fly   370 KLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFR 434
            :|..|...|||::||.|....:.|..|::..|.:|.::|||:...:.:|.||.||..|..||.|.
  Rat   379 QLPFLTMCIKESLRLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVFD 443

  Fly   435 PERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE-----IDPKTIV 494
            |.||..||.|.|...::||||||.||||||.|||.|||.::...|.:|::||:     ..|:.|:
  Rat   444 PFRFDSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFRVLPDDKEPRRKPEIIL 508

  Fly   495 -FQTGLTLR 502
             .:.||.||
  Rat   509 RAEGGLWLR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	148/464 (32%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	146/461 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850