DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	169/534 - (31%)
Similarity:	254/534 - (47%)	Gaps:	67/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVGAFIVLIQWI---YRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYG 63
            |:|.|:||..:|::.:   |...|.|..|..|.        |.|:            .|.|
  Rat    20 LLLLLIGASWLLVRVLTQTYIFYRTYQHLCDFP--------QPPK------------WNWF---- 60

  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMG--------TAIYNVIDADSAERVLN-DPNLINKGTI-Y 118
            ..|.|:...:....|::.|..|.|..|        ..|..:...|....||: ..::..|..| |
  Rat    61 LGHLGMITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFY 125

  Fly   119 DFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAII 179
            .||.|:|..|||.|.|.||...|:||:|.||||||..:.:|| .:|...:    :.......|.:
  Rat   126 SFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIF-NDSTNIMHAKWQDLASGGSARL 189

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE- 243
            .:.:.|...||:|:.:...... ....||...|.....::.....:|....||.:|:|:::...
  Rat   190 DMFKNISLMTLDSLQKCVFSFD-SNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNG 253

  Fly   244 KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLD----TLILAEKD 304
            :.:..|..:||.|:..:|..||..|..:         .||::..:|.|...||    .|:..::|
  Rat   254 RRFHKACKLVHNFTDAVIQGRRRALPSQ---------HEDDILKAKARSKTLDFIDVLLLTKDED 309

  Fly   305 G--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI-DDELNILNIG 366
            |  |.|. .|..|.||.||||:|||:.||.:.|.|::.:||.||:|.||::..: |.|...:...
  Rat   310 GKELSDE-DIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWD 373

  Fly   367 QLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPE 431
            .|.:|..|...|||::||.|.|..:.|..|::..|.:|.::|||....:::|..|.||..|..||
  Rat   374 DLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPE 438

  Fly   432 EFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE-----IDPK 491
            .:.|.||.|||.::|...|:||||||.||||||.|||.|||..:...|.:|::||:     ..|:
  Rat   439 VYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPE 503

  Fly   492 TIV-FQTGLTLRTK 504
            .|: .:.||.||.:
  Rat   504 LILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	156/479 (33%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	150/452 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850