DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	442	Identity:	173/442 - (39%)
Similarity:	251/442 - (56%)	Gaps:	41/442 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 AIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQF 156
            |:||   |::.|.:|.....|:|.::|.||.|:|..|||||||.||.:|||||:|||||.||..|
Human   101 ALYN---AENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDF 162

  Fly   157 QEIFITES---LKFLEQFKGNDEAI-----ISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYR 213
            .:|...::   :|.||:.. |.||.     |:|      ..|:.|||||||..:...:.....|.
Human   163 LDIMNEQANILVKKLEKHI-NQEAFNCFFYITL------CALDIICETAMGKNIGAQSNDDSEYV 220

  Fly   214 ENFRQIEECFIRRMSNPLLWSDTLFKMFAEK-DYASALDVVHGFSSEIIAKRRDQLNDEIDSRGN 277
            ....::.|...||:..|.||.|..:.||.|. ::..:|.::|.|::.:||:|.:::|...|.||:
Human   221 RAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGD 285

  Fly   278 TQTAEDELFTSKKRFAMLDTLILAEKD--GLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSL 340
            .:.:..   :..||.|.||.|:....|  ..:.|..|.|||||.||||:|||:..:.:.|..:..
Human   286 GRGSAP---SKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGS 347

  Fly   341 YPEEQEKCYQEIQANIDDELNIL--------NIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTR 397
            .||.|:|        :|.||:.:        .:..|.||:.||..||||:|||||||...|..:.
Human   348 NPEVQKK--------VDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSE 404

  Fly   398 ETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCI 462
            :.|::...:| ||::..:..:.:||:|.|:.:||||:||||.|||:|.||.|||:|||||.||||
Human   405 DCEVAGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCI 468

  Fly   463 GQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVKLVRR 514
            |||||:.|.||::..:|:.|.|......:.:..:..|.||..|.|.:||.||
Human   469 GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	167/431 (39%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	169/437 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950