DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	166/440 - (37%)
Similarity:	236/440 - (53%)	Gaps:	37/440 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 AIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQF 156
            |:|.   |::.|.:|.....|:|..:|.||.|:|..|||||||.||.||||||:|:|||.||..|
  Rat   101 ALYK---AENVEVILTSSKQIDKSFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDF 162

  Fly   157 QEIFITESLKFLEQFKGNDEAIISLNEV--------------IPRFTLNSICETAMGVKLDEMAE 207
            .::.             |::|.|.:|::              |....|:.|||||||..:...:.
  Rat   163 LDVM-------------NEQANILVNKLEKHVNQEAFNCFFPITLCALDIICETAMGKNIGAQSN 214

  Fly   208 KGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE-KDYASALDVVHGFSSEIIAKRRDQLNDE 271
            ....|.....::.:...|||..|..|.|..:.||.| :|:...|..:|.|::.:||:|.:....|
  Rat   215 GDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTNNVIAERVNARKAE 279

  Fly   272 IDSRGNTQTAEDELFTSKKRFAMLDTL--ILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFG 334
            .|..|   .....|.:..||.|.||.|  :..|:...:.|..|.|||||.||||:|||:..:.:.
  Rat   280 QDCIG---AGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINWS 341

  Fly   335 LMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRET 399
            |..:...||.|.|..:|:..........:.:..|.|||.|:..||||:|:|||||...|..:.:.
  Rat   342 LYLLGSNPEVQRKVDKELDDVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDC 406

  Fly   400 ELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQ 464
            |:: |..:.||::..:..:.:||:|.|:..||||:||||.|||||.||.|||:|||||.||||||
  Rat   407 EVA-GYKISKGTEAVIIPYALHRDPRYFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQ 470

  Fly   465 KFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVKLVRR 514
            |||:.|.||::..:|::|.|......:.:.....|.||..|.|.:||.||
  Rat   471 KFAVMEEKTILACILREFWIESNQKREELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	160/429 (37%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	162/433 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950