DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	154/544 - (28%)
Similarity:	257/544 - (47%)	Gaps:	92/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLY-GKDHS 67
            ||   |.:|::..|        :|..|:..:|.:.                .|.:.|.: |....
  Rat    15 LW---ASVVILMVI--------VLKLFSLLLRRQK----------------LARAMDSFPGPPTH 52

  Fly    68 GVFEHSRDCAKKLGK-----SYAE---------YAMGTAIYNVIDADSAERVLN--DPNLINKGT 116
            .:|.|:.: .:|||.     |:|:         :.......|:.:.|.|:.|.:  ||...:
  Rat    53 WLFGHALE-IQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAAD--- 113

  Fly   117 IYDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQF--KGNDEAII 179
            :|||...::..|||...|.||...||:|:|.||:::|..:..||...:...|:::  |.::....
  Rat   114 VYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSF 178

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDR---YREN--FRQIEECFI---RRMSNPLLWSDT 236
            .:...:....|:::.:...|        |||.   :|:|  :..:.:..:   :|:.:....:|.
  Rat   179 DIFCDVGHMALDTLMKCTFG--------KGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDF 235

  Fly   237 LFKMFAE-KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLIL 300
            ::.:... :.:..|..:.|..:.|:|.:|:..|.||         .|.:....::....||.|:
  Rat   236 IYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDE---------KERKKIQQRRHLDFLDILL- 290

  Fly   301 AEKDGLIDHIGI-------CEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDD 358
                |:.|..||       ..||||.||||:|||:.|:.:.|..|:||||.|:.|.:|::..:.|
  Rat   291 ----GVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGD 351

  Fly   359 ELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRN 423
            : :......|.|:..|...:||..||:|.||.:.|:..:.....:|..||.||.|.:|::.:|||
  Rat   352 Q-DSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRN 415

  Fly   424 PEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEI 488
            ...|..||.|.|.||.|||:..||.:|::|||||.||||||:|||.|||.:....|.:|:.  .:
  Rat   416 STVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF--SL 478

  Fly   489 DPKTIVFQT-GLTLRTKNQIHVKL 511
            ||..:..:. .|.||:||.||:.|
  Rat   479 DPSKMPIKVPQLILRSKNGIHLYL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	141/486 (29%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	142/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850