DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and cyp-29A2

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_505847.1	Gene:	cyp-29A2 / 179550	WormBaseID:	WBGene00011830	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	521	Identity:	163/521 - (31%)
Similarity:	241/521 - (46%)	Gaps:	62/521 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILGFFAKRIRT----KNGQNPESIAPLVKGSTIFANSFDLYGK---DHSGVF----------EHS 73
            ||.:.|..|.|    |......|..|......||.|...:.||   |...||          .||
Worm    12 ILAYLATWIPTLLKYKRHWQYGSKLPGPPAHPIFGNLGPIVGKKTEDLPSVFINWAAEQRDQGHS 76

  Fly    74 RDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTG-LLTSTGKKW 137
            ......|||.||....|.|...:||:.:.         .|||..|.|..|:|..| ||...|::|
Worm    77 VMRVMILGKVYAWPLNGKAAAAIIDSTTE---------TNKGDDYRFFDPWLGGGLLLEGYGERW 132

  Fly   138 HARRKMLSPTFHFNILNQFQEIFITES---LKFLEQFKGNDEAIISLNEVIP---RFTLNSICET 196
            .:.||||:|.|||..|..:.|:|..||   :..|..|..:.|.:    ::.|   |..|:.|.||
Worm   133 KSHRKMLTPAFHFAKLGGYFEVFNNESKILIDLLSDFSASGETV----DIFPYVKRCALDIISET 193

  Fly   197 AMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAEK----DYASALDVVHGFS 257
            |||:|:|.......:|.:......:..:....||.|.:..:|.....|    ||.|.|..:
Worm   194 AMGIKIDAQINHDHKYVQAVEGYNKIGVLVSFNPHLKNQFIFWATGYKAQYDDYLSTLKSM---- 254

  Fly   258 SEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFE 322
            :|.:.|.|...:|         :.|.|..|||:....||.::..|:...:....|.:||||.||.
Worm   255 TEKVIKERRAAHD---------SGEVEKETSKRMMNFLDLMLSMEESNQLTSEDIRQEVDTFMFA 310

  Fly   323 GYDTTSIGLMFGLMNMSLYPEEQEKCYQE-IQANIDDELNILNIGQLNKLKNLEYFIKETMRLFP 386
            |:|||:....:...|::..|..|||.|:| |:...||....:.:..:|.|..|:..:||:.|:..
Worm   311 GHDTTTSSTSWACWNLAHNPNVQEKVYKEMIEVFGDDPNTDITLENVNNLNYLDIVLKESKRIIA 375

  Fly   387 SVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAY 451
            .|||:.|:.|.:.|: :|.|:|.|..:.:....:|.|...:.:|.||.|:||||:....||.|.:
Worm   376 PVPALQRKLTNDLEI-DGYIVPAGGNVTISPMVLHSNHHVFKNPTEFNPDRFLPDEVSKRHPYDF 439

  Fly   452 IPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEI---DPKTIVFQTGLTLRTKNQIHVKLVR 513
            :||.||.|||||||||....|.::..:::.|:|.|.:   |.|..:   .:..:..|.|.|:|:|
Worm   440 MPFLAGPRNCIGQKFAQLNEKVMISHIVRNFKIEPTLKYNDTKPCL---EVVTKPSNGIPVRLIR 501

  Fly   514 R 514
            |
Worm   502 R 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	149/478 (31%)
cyp-29A2	NP_505847.1	p450	37..495	CDD:278495	151/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030