DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	542	Identity:	157/542 - (28%)
Similarity:	249/542 - (45%)	Gaps:	87/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLY-GKDHS 67
            ||..|..:|              |||.            :.|..|::..|: |.:.|.: |....
Human    15 LWASGLILV--------------LGFL------------KLIHLLLRRQTL-AKAMDKFPGPPTH 52

  Fly    68 GVFEHSRDCAK--KLGK--------SYAE---YAMGTAIYNVIDADSAERVLN--DPNLINKGTI 117
            .:|.|:.:..:  .|.|        .||.   :.......|:.:.|.|:.|.:  ||...:   :
Human    53 WLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD---V 114

  Fly   118 YDFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLK-FLEQF--KGNDEAII 179
            |||...::..|||...|.||...||:|:|.||:::|..:..:| |||.: .|:::  |..:....
Human   115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVF-TESTRIMLDKWEEKAREGKSF 178

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSN-PLLWSDTLFKMFAE 243
            .:...:....||::.:...|        :||....:.|  :..:...:|: .||....|......
Human   179 DIFCDVGHMALNTLMKCTFG--------RGDTGLGHSR--DSSYYLAVSDLTLLMQQRLVSFQYH 233

  Fly   244 KD-----------YASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDT 297
            .|           :..|..|.|..:.::|.:|:..|.|| ..|...|        :::....||.
Human   234 NDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDE-KVRKKIQ--------NRRHLDFLDI 289

  Fly   298 LILA--EKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDEL 360
            |:.|  |.|..:....:..||||.||||:|||:.|:.:.|..|:||||.|.:|.:|::..:.|:
Human   290 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ- 353

  Fly   361 NILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPE 425
            :......|.|:..|...|||:.||:|.||.:.|:.::.....:|..||.||.|.:|::.:|||..
Human   354 DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

  Fly   426 YWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDP 490
            .|..||.|...||..||:..||.:|::|||||.||||||:|||.|||.:....|.:|:.  .:||
Human   419 VWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF--SLDP 481

  Fly   491 KTI-VFQTGLTLRTKNQIHVKL 511
            ..: :....|.||:||..|:.|
Human   482 SRLPIKMPQLVLRSKNGFHLHL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	143/484 (30%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	143/479 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850