Protein Alignment Cyp4p3 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_610473.1
• Gene: Cyp4p3 / 35948
• FlyBaseID: FBgn0033397
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 117/453 - (25%)
• Similarity: 203/453 - (44%)
• Gaps: 71/453 - (15%)

  Fly    66 HSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINK------GTIYDFLHPF 124
            |.|......:|.||.||.:..|          |.......:.||::|..      .:::....||
Human    54 HKGFCMFDMECHKKYGKVWGFY----------DGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF 108

  Fly   125 LRTGLLTST-----GKKWHARRKMLSPTFHFN-------ILNQFQEIFITESLKFLEQFKGNDEA 177
            ...|.:.|.     .::|...|.:|||||...       |:.|:.::.:....:..|..|.
Human   109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP---- 169

  Fly   178 IISLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIR-RMSNPLLWSDTLFKMF 241
             ::|.:|...::::.|..|:.||.:|.:....|.:.||.:::    :| ...:|...|.|:|...
Human   170 -VTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL----LRFDFLDPFFLSITVFPFL 229

  Fly   242 AEKDYASALDVVH--GFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLI----- 299
                 ...|:|::  .|..|:....|..:....:||     .||   |.|.|...|..:|
Human   230 -----IPILEVLNICVFPREVTNFLRKSVKRMKESR-----LED---TQKHRVDFLQLMIDSQNS 281

  Fly   300 -LAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDEL--- 360
             ..|....:..:.:..:....:|.||:|||..|.|.:..::.:|:.|:|..:||.|.:.::.
Human   282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346

  Fly   361 --NILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRN 423
              .:|      :::.|:..:.||:||||....:.|...::.|: ||:.:|||..:.:..:.:||:
Human   347 YDTVL------QMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRD 404

  Fly   424 PEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILP 486
            |:||..||:|.||||..:|..|...|.|.||.:|.|||||.:||:..||..::.:|:.|...|
Human   405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	117/453 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	117/453 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910