DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	447	Identity:	135/447 - (30%)
Similarity:	232/447 - (51%)	Gaps:	29/447 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CAKKLGKSYAEYAMGTAIY-NVIDADSAERVL--NDPNLINKGTIYDFLHPFLRTGLLTSTGKKW 137
            |.:....::..:..|:..| .|.|.|..:.:|  :||   .....|..|.|::..|||...|:.|
Mouse    77 CIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDP---KANGAYRLLAPWIGYGLLLLNGQPW 138

  Fly   138 HARRKMLSPTFHFNILNQFQEIFITESLKFLEQFK--GNDEAIISLNEVIPRFTLNSICETAMGV 200
            ...|:||:|.||::||..:.:.........|::::  .:.::.|.:.:.|...||:::.:.|...
Mouse   139 FQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSH 203

  Fly   201 KLDEMAEKGDR-YRENFRQIEECFIRRMSNPLLWSDTLFKMFAEKDYA-SALDVVHGFSSEIIAK 263
            |.....:...| |.:....:...|..|:.|....:||::|:.:....| .|..:.|..:..:|..
Mouse   204 KGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKL 268

  Fly   264 RRDQLNDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEK---DGLIDHIGICEEVDTLMFEGYD 325
            |:|||.||         .|.|....|:|...||.|:.|..   |.:.|. .:..||||.||||:|
Mouse   269 RKDQLQDE---------GELEKIKKKRRLDFLDILLFARMENGDSMSDK-DLRAEVDTFMFEGHD 323

  Fly   326 TTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPA 390
            ||:.|:.:....::.:|:.|::|.:|:|:.:.|..:| ....|:::......|||.:||:|.||.
Mouse   324 TTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSI-TWDHLDQIPYTTMCIKEALRLYPPVPG 387

  Fly   391 MGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFS 455
            :.||.:......:|..||||.|:.:.::.:|.||:.|.:||.|.|.||.|::.  ||:::::|||
Mouse   388 IVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSP--RHSHSFLPFS 450

  Fly   456 AGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTG-LTLRTKNQIHVKL 511
            .|.|||||::|||.|:|.::...|.:|::||  ||..:..... |.|::||.|::.|
Mouse   451 GGARNCIGKQFAMSELKVIVALTLLRFELLP--DPTRVPMPLARLVLKSKNGIYLHL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	131/439 (30%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	134/443 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840