DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p3 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	534	Identity:	167/534 - (31%)
Similarity:	255/534 - (47%)	Gaps:	67/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LILWLVGAFIVL---IQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYG 63
            |:|.:|||..:|   :.|.|....:       .:|:|         ..|..:....|..
Human    20 LLLLVVGASWLLARILAWTYAFYHN-------GRRLR---------CFPQPRKQNWFLG------ 62

  Fly    64 KDHSGVFEHSRDCAKKLGKSYAEYAMG--------TAIYNVIDADSAERVLNDPNLINKGTI--Y 118
              |.|:...:.:..:.|.:..|.|..|        |.|.|:...|....|:|..:.|....|  |
Human    63 --HLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFY 125

  Fly   119 DFLHPFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFL----EQFKGNDEAII 179
            ..|.|:|..|||.|.|.||...|::|:|.||||||..:.:|| ::|...:    ::........:
Human   126 KTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIF-SKSANIMHAKWQRLAMEGSTCL 189

  Fly   180 SLNEVIPRFTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMF-AE 243
            .:.|.|...||:|:.:...... ....||...|.....::....::|.:....:.|.|:.:. ..
Human   190 DVFEHISLMTLDSLQKCIFSFD-SNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCG 253

  Fly   244 KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDELFTSK---KRFAMLDTLILAE-KD 304
            :.:..|..:||.|:..:|.:||..|         |....|:...:|   |....:|.|:|:| |:
Human   254 RRFHRACRLVHDFTDAVIQERRRTL---------TSQGVDDFLQAKAKSKTLDFIDVLLLSEDKN 309

  Fly   305 G--LIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDD-ELNILNIG 366
            |  |.|. .|..|.||.||.|:|||:.||.:.|.|::.:||.||:|.||:|..:.| |...:...
Human   310 GKELSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWD 373

  Fly   367 QLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPE 431
            .|.:|..|...:||::||.|.:|...|..|::..|.:..::|||:...:::|.||.||..|..||
Human   374 DLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPE 438

  Fly   432 EFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPE-IDPK---T 492
            .:.|.||.|||:|.|...|:||||||.||||||||||.|||.::...|.:|:|||: .:|:   .
Human   439 VYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPE 503

  Fly   493 IVF--QTGLTLRTK 504
            ||.  :.||.||.:
Human   504 IVLRAEDGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	156/479 (33%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	151/471 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850