DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	114/555 - (20%)
Similarity:	226/555 - (40%)	Gaps:	108/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMICLLWISVAILVVIHWIY-KVNKDYNILAFFAR--------RVQTKDGKPLDSLVPMIKGRTV 56
            |.:..:.:.|...:|..:|| .:...:.|.:.|.:        |:.:.:...:..|....|.:.:
plant     1 MAVFFILVLVFFFLVFRFIYSNIWVPWRIQSHFKKQSVTGPSYRIFSGNSGEVSRLTAEAKSKPI 65

  Fly    57 FANCFDLLGKD----TDQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKG 117
            .:      |::    ..:|..|..:.::..|.::|.:   |.:..|:       ..:.|.||.:.
plant    66 PS------GRNPHEFVHRVAPHYHEWSRVYGKTFLYW---FGSKPVV-------ATSDPRLIREA 114

  Fly   118 VI---------YNFLHPFL-RTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQ 172
            :.         :|.|...| ..|:......:|...|.:..:.|.::.|.::....:..::..:.:
plant   115 LTTGGSFDRIGHNPLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLMEK 179

  Fly   173 FQ----GQNEVVVSLKDRISRFTLNSICETAMGIKLDE---MAEKGDRYRANFHIIDEGLTRRIV 230
            ::    |..|:.:.:...:...:...:..||.|..::|   :.|..:|....|:::
plant   180 WEDMRNGGEEIELEVHKEMHNLSAEMLSRTAFGNSVEEGKGIFELQERMMRLFYLV--------- 235

  Fly   231 NPLYWDDCVYNMFTGHKYNAALKVVHEFSREI--IAKR-RVLLEEELENRRATQTADDDICVIRK 292
               .|.  ||  ..|.::..:     :.:|||  |.|: ||.:.:.:||.:...          :
plant   236 ---RWS--VY--IPGFRFFPS-----KTNREIWRIEKQIRVSILKLIENNKTAV----------E 278

  Fly   293 KRFAMLDTLIC--AEKDGLIDDIGISEEVD---TLMAEGYDTTSIGLVFGLMNMSL------YAA 346
            |...:|...:.  ..::|..:.:||.|..|   |......:||:..:.|.|:.:::      .|.
plant   279 KSGTLLQAFMSPYTNQNGQEEKLGIEEVTDECKTFYFAAKETTANLMTFVLVLLAMNQEWQNIAR 343

  Fly   347 EQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILP 411
            |:.:|       :|.......|..|..|..|...|.||:||||....:.|.||:..:| ..|.:|
plant   344 EEVIC-------VLGQTGLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAKL-GDLDIP 400

  Fly   412 KRSQINIHVFDIHRNPKYW-ESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMK 475
            ..:|:.:.|..:|.:.:.| :..|||.|.||...   |:.....:||..|.|.|:||..|:.|.|
plant   401 AGTQLYLSVVAMHHDKETWGDDAEEFNPRRFEDP---KKQSALLVPFGLGPRTCVGQNLAVNEAK 462

  Fly   476 TLMVVILKH--FKILPVIDPKSIVFQVGITLRFKN 508
            |::..|||:  |::.|......::|   :||:.:|
plant   463 TVLATILKYYSFRLSPSYAHAPVLF---VTLQPQN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	104/484 (21%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	109/530 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050