Protein Alignment Cyp4p2 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 152/529 - (28%)
• Similarity: 238/529 - (44%)
• Gaps: 100/529 - (18%)

  Fly     7 WISVAILV-------VIHWIYKVNKDYNILAFF--ARRVQTKDGKPLDSLVPMIKGRTVFANCFD 62
            |:.:.::|       ::.|.|         ||:  .||:|         ..|....|..|.....
Human    19 WLLLLLVVGSWLLARILAWTY---------AFYNNCRRLQ---------CFPQPPKRNWFWGHLG 65

  Fly    63 LLGKDTDQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITK----------- 116
            |:        |...:..|||......||.||:.:  :.......:|.||:.|..
Human    66 LI--------TPTEEGLKNSTQMSATYSQGFTVW--LGPIIPFIVLCHPDTIRSITNASAAIAPK 120

  Fly   117 -GVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQ---GQN 177
             .:...||.|:|..|:|.:...||...|.|||..||.:||..:..||...:...:.::|   .:.
Human   121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185

  Fly   178 EVVVSLKDRISRFTLNSI----------CE------TAMGIKLDEMAEKGDRYRANFHIIDEGLT 226
            ...:.:.:.||..||:|:          |:      .|..::|..:.||..:     ||:.
Human   186 SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQ-----HILQ---- 241

  Fly   227 RRIVNPLYWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADD---DIC 288
                   :.|...|....|.:::.|.::||:|:..:|.:||..|        .||..||   |
Human   242 -------HMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTL--------PTQGIDDFFKD-- 289

  Fly   289 VIRKKRFAMLDTLICA-EKDG-LIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELC 351
            ..:.|....:|.|:.: ::|| .:.|..|..|.||.|..|:|||:.||.:.|.|::.:...||.|
Human   290 KAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 354

  Fly   352 YQEIQEHILD-DLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQ 415
            .||:||.:.| |...:....|::|.:|...:||::||:|..|.:.|...|:..|.:|.::||...
Human   355 RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGIT 419

  Fly   416 INIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVV 480
            ..|.:..:|.||..|..||.:.|.||.|:|...|.|.|:||||||.||||||.:||.|||.::.:
Human   420 CLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484

  Fly   481 ILKHFKILP 489
            :|.||:.||
Human   485 MLLHFRFLP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	140/464 (30%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	143/478 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850