Protein Alignment Cyp4p2 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 121/543 - (22%)
• Similarity: 237/543 - (43%)
• Gaps: 99/543 - (18%)

  Fly     7 WISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQV 71
            |:.||..:|:.:||..:         :.::..|.|.|..:.:|.: |..:|
Human    12 WVLVATSLVLLYIYGTH---------SHKLFKKLGIPGPTPLPFL-GTILF-------------- 52

  Fly    72 FTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVI---YNF------LHP-- 125
              :||.|.....:...:|.   ..:.:.:......::..|::|...::   |:.      |.|
Human    53 --YLRGLWNFDRECNEKYG---EMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG 112

  Fly   126 FLRTGVLTATEKKWHTRRSMLTRTF-------HLDILNQFQEIFIAESLKFVSQFQGQNEVVVSL 183
            ||::.:..|.:::|...|::|:..|       .:.|::|..::.: .||:    .:.:|...::|
Human   113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV-RSLR----QEAENSKSINL 172

  Fly   184 KDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMFTG--H 246
            ||....:|::.|..|..|:.||.:....|.:..|...:   |....::|......::...|.  .
Human   173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL---LKLDFLDPFLLLISLFPFLTPVFE 234

  Fly   247 KYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKD---- 307
            ..|..|     |.:::..    .|:..:|..:.::..|.     :|.|......:|.::..
Human   235 ALNIGL-----FPKDVTH----FLKNSIERMKESRLKDK-----QKHRVDFFQQMIDSQNSKETK 285

  Fly   308 --GLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQ 370
              ..:.|:.:..:...::...|||||..|.|.:..::.:...|:...:|| :.:|.:.:.:....
Human   286 SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTYDA 349

  Fly   371 LSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEE 435
            |.::.||...:.||:||:|.:..:.|...::.|: ||:.:||...:.:.::.:|.:||||..||:
Human   350 LVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEK 413

  Fly   436 FRPE-RFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKI------------ 487
            |.|| ||..:|......|.||||.||.|||||.::|:..:|..::..|::|..
Human   414 FCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKL 478

  Fly   488 --LPVIDP-KSIVFQV----GIT 503
              ||::.| |.||.:|    |||
Human   479 DNLPILQPEKPIVLKVHLRDGIT 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	109/487 (22%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	109/498 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910