DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	521	Identity:	158/521 - (30%)
Similarity:	246/521 - (47%)	Gaps:	64/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQV 71
            ||...||:.|:..|   ::|..|..|.   |......|...|.|:              ..|:|
Mouse    29 WILARILIQIYAAY---RNYRHLHGFP---QPPKRNWLMGHVGMV--------------TPTEQ- 72

  Fly    72 FTHLRQLAKNSGDSYLQYSMGFSNF--------NVIDAHNAANILNHPNLIT-KGVI-YNFLHPF 126
              .|::|.:..|    .|..||..:        .:..:....:|||....:. |.|| |:.|.|:
Mouse    73 --GLKELTRLVG----TYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPW 131

  Fly   127 LRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQ---GQNEVVVSLKDRIS 188
            |..|:|.:...||...|.|||..||.:||..:.:||...:....:::|   ......:.:.:.:|
Mouse   132 LGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEHVS 196

  Fly   189 RFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMF-TGHKYNAAL 252
            ..||:|:.:...... ....||...|.|....:...:.:|...||.:.|.:||:. .|.::..|.
Mouse   197 LMTLDSLQKCVFSFD-SNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKAC 260

  Fly   253 KVVHEFSREIIAKR-RVL----LEEELENRRATQTADDDICVIRKKRFAMLDTLICA-EKDGL-I 310
            .|||||:..:|.:| |.|    |::.|:::..::|.|            .:|.|:.: ::||. :
Mouse   261 NVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD------------FIDVLLLSKDEDGKEL 313

  Fly   311 DDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILD-DLSNLNLSQLSKL 374
            .|..|..|.||.|.||:|||:.||.:.|.|::.:...||.|.||:||.:.. :...:....|::|
Mouse   314 SDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQL 378

  Fly   375 NYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPE 439
            .:|...|||::||:|.:.::.|...|:..|.:|..:||.....|.:|.||.||..|..||.:.|.
Mouse   379 PFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPF 443

  Fly   440 RFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITL 504
            ||.|:|.....|.|:||||||.||||||.:||.|||..:.:.|..|::||  |.|....|..:.|
Mouse   444 RFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLP--DDKEPRRQPELIL 506

  Fly   505 R 505
            |
Mouse   507 R 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	145/465 (31%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	149/495 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2076
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.880