DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	543	Identity:	167/543 - (30%)
Similarity:	266/543 - (48%)	Gaps:	74/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTD 69
            :|:.:|.:|::....|...|:|        ..:..:.:|:..:          |..:.::|
Zfish    12 ILFTAVLLLLLASTAYNPLKNY--------IGKWNEMRPIPGM----------AGAYPIIG---- 54

  Fly    70 QVFTHLRQLAKNSGDSYLQYSMGFSNFN-----------------VIDAHNAANILNHPNLITKG 117
                :..|...|:||.:.|...| :|.|                 :..|.|...:|::...:.|.
Zfish    55 ----NALQFKTNAGDFFNQIIEG-TNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKS 114

  Fly   118 VIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQNEVVVS 182
            ..|.||||:|.||:||:|.:||..||.|||.|||..||:.|.|:...::...:.:.|       .
Zfish   115 YSYRFLHPWLGTGLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQ-------K 172

  Fly   183 LKDR--------ISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCV 239
            |:|.        |:...|:.|||||||.|:...:.....|..:.:.:.:.:|:|...|..|.|.:
Zfish   173 LEDGEPFNCFNFITLCALDIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWI 237

  Fly   240 YN-MFTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLI- 302
            || :..|.::...||::|.|:..:|.:|...:..|         .|.|.....:||.|.||.|:
Zfish   238 YNKLKEGKEHAKRLKILHSFTANVIRERAEFMSSE---------PDSDSDQGERKRQAFLDMLLK 293

  Fly   303 -CAEKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNL 366
             ..|....:....|.|||||.|.||:|||:..:.:.|..:..:...|:....|:||.......::
Zfish   294 TTYENGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHV 358

  Fly   367 NLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWE 431
            .:..|.||.||...|||::|::||:|:..|...:...: ||..:||.....|..:.:||:|:|:.
Zfish   359 GVEDLKKLRYLECVIKESLRIFPSVPLFARSICEACHI-NGFKVPKGVNAVIIPYALHRDPRYFP 422

  Fly   432 SPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSI 496
            .||||:||||:|:|...||||||||||||.||||||::||.|.|.::..||:||.: .....:..
Zfish   423 EPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDV-EACQSREE 486

  Fly   497 VFQVG-ITLRFKNKIKVKLVRRN 518
            :..:| :.||.:..|.:||.||:
Zfish   487 LRPLGELILRPEKGIWIKLQRRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	155/479 (32%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	156/497 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950