DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	529	Identity:	174/529 - (32%)
Similarity:	272/529 - (51%)	Gaps:	56/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQVFT 73
            ||.::...:..|::.|.|        ..:.|:.||:..:          .|.|..:|....
Zfish    16 SVCVICFAYITYQLLKSY--------LHKWKELKPIPGI----------GNTFPFIGNALQ---- 58

  Fly    74 HLRQLAKNSGDSYLQ---YSMGFSNFNVI-------------DAHNAANILNHPNLITKGVIYNF 122
                 .|::||.:||   |:..|.|..::             .|.....:||:|..|.|...|.|
Zfish    59 -----FKSNGDFFLQLVGYTTEFQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQF 118

  Fly   123 LHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQ-NEVVVSLKDR 186
            |||:|.||:||:|..||..||.|||.|||..||.:|.|:...::...:.:.:.| .:...:....
Zfish   119 LHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSH 183

  Fly   187 ISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYN-MFTGHKYNA 250
            |:...|:.|||||||.::...:.....|....:.:.:.:|||...|.||.|.||| :..|.::|.
Zfish   184 ITLCALDIICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNR 248

  Fly   251 ALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLI-CAEKDG-LIDDI 313
            :||::|.|:..:|.:|    .|.|....:...:|..:    :||.|.||.|: ..::|| ::...
Zfish   249 SLKILHSFTESVINER----AEYLSYVESDSESDQGM----RKRRAFLDMLLKTKDEDGKMLTHK 305

  Fly   314 GISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLG 378
            .|.|||||.|.||:|||:..:.:.:..:..:...|....||:.|...:....:|...|.||.||.
Zfish   306 DIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESERPVNTEDLKKLRYLE 370

  Fly   379 YFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLP 443
            ..|||::||:||:|...|....:|:: ||..:||.:.|.:..:.:||:|:::..|||||||||||
Zfish   371 CVIKESLRLFPSVPFFARTICDDTQI-NGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLP 434

  Fly   444 QNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITLRFKN 508
            :||:.||||||||||||.||||||::|:.|.|.::..||::|.|:.....:.:.....:.||.:.
Zfish   435 ENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREELRPLGELVLRPEQ 499

  Fly   509 KIKVKLVRR 517
            .|.:.|.||
Zfish   500 GIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	161/470 (34%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	162/484 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950