DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	142/503 - (28%)
Similarity:	237/503 - (47%)	Gaps:	49/503 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLWISVAILV--VIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKD 67
            ||.:..::|:  ::.||.....:|..|..|                |....|..|....:|: |:
  Rat    22 LLVVGTSLLLARILAWISAFYDNYCRLRCF----------------PQPPSRHWFWGHLNLV-KN 69

  Fly    68 TDQVFTHLRQLAKNSGDSYLQY-SMGFSNFNVIDAHNAANILNHPNLIT--KGVIYNFLHPFLRT 129
            .::....|.:::....|.:|.: .:.:....:|.......||..|..:.  :.:.|.||.|:|..
  Rat    70 NEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQAPAAVAPKEMIFYGFLKPWLGD 134

  Fly   130 GVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFV----SQFQGQNEVVVSLKDRISRF 190
            |:|.:..:||..:|.:||..||.|||..:.:.| .:|:..:    .:...:....:.:.:.||..
  Rat   135 GLLVSAGEKWSRQRRLLTPAFHFDILKPYVKNF-NKSVNIMHAKWQRLTAKGSARLDMFEHISLM 198

  Fly   191 TLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNP-LYWDDCVYNMFTGHKYNAALKV 254
            ||:|:.:...... ....|....|.|....:...:.:|...| ||.|...|....|.::..|..:
  Rat   199 TLDSLQKCVFSFD-SNCQESPSEYIAAIQELSSLIVKRHHQPFLYMDFLYYLTADGRRFRKACDL 262

  Fly   255 VHEFSREIIAKRRVLL-----EEELENRRATQTADDDICVIRKKRFAMLDTLICA--EKDGLIDD 312
            ||.|:..:|.:||..|     :|.|:::..::|.|            .:|.|:.|  |....:.|
  Rat   263 VHNFTDAVIRERRRTLSSQSVDEFLKSKTKSKTLD------------FIDVLLLAKDEHGKELSD 315

  Fly   313 IGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILD-DLSNLNLSQLSKLNY 376
            ..|..|.||.|..|:|||:..|.:.|.|::.:...||.|.||::|.:.| :...:....|::|.:
  Rat   316 EDIRAEADTFMFGGHDTTASALSWILYNLARHPEHQERCRQEVRELLRDREPEEIEWDDLTQLPF 380

  Fly   377 LGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERF 441
            |...|||::||:|.:.::.|...|:..|.:|.::||.:...|.:|.:|.||..|..||.:.|.||
  Rat   381 LTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGNDCIISIFGVHHNPSVWPDPEVYDPFRF 445

  Fly   442 LPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILP 489
            ..:|..||.|.|:||||||.||||||.:||.|||..:.:.|..|::||
  Rat   446 DSENPQKRSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRLLP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	131/443 (30%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	134/457 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850