DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	160/534 - (29%)
Similarity:	271/534 - (50%)	Gaps:	58/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQVFT 73
            |:.|.:|::     ||..:.|..:..::      |..:.:|.: |..:..|.      |.|::|.
  Fly    36 SILIFLVVY-----NKRRSRLVKYIEKI------PGPAAMPFL-GNAIEMNV------DHDELFN 82

  Fly    74 HLRQLAKNSGDSYLQYSMGFS--------NFNVIDAHNAANILNHPNLITKGVIYNFLHPFLRTG 130
            .:..:.|..|.     .:|.:        ...:.:......|||....:.|...|::|||:|..|
  Fly    83 RVIGMQKLWGT-----RIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEG 142

  Fly   131 VLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQ-NEVVVSLKDRISRFTLNS 194
            :||:|::|||:||.:||..||..||:.|.::|..:|.....:...: .....:|...::..||:.
  Fly   143 LLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDI 207

  Fly   195 ICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMFTGHK-YNAALKVVHEF 258
            :||||||.::...:.....|....:.|...:..|........|.::::...:| :.:.:..:|.|
  Fly   208 VCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGF 272

  Fly   259 SREIIAKRR----VLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDG-LIDDIGISEE 318
            |..:|.:|:    :|.|....|......|.||  |.:|||.|.||.||.|.|:| ::.:..|.||
  Fly   273 SNMVIRERKAELAILQENNNNNNNNAPDAYDD--VGKKKRLAFLDLLIDASKEGTVLSNEDIREE 335

  Fly   319 VDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNL---------NLSQLSKL 374
            |||.|.||:||||..:.:.|..:.        |:.|.||.::::|.::         .:..|..:
  Fly   336 VDTFMFEGHDTTSAAISWTLFLLG--------CHPEYQERVVEELDSIFGDDKETPATMKNLMDM 392

  Fly   375 NYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPE 439
            .||...||:::||:||:|:|.|...::..: .|.|:|..:|..|..:.:||||:.:..||:|.|:
  Fly   393 RYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPD 456

  Fly   440 RFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITL 504
            .|||:||..|||:||||||||.|||||||:|:.|.|.::..:|:.:||..|...:.:.....:.|
  Fly   457 NFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELIL 521

  Fly   505 RFKNKIKVKLVRRN 518
            |.|:.::||:..|:
  Fly   522 RPKDGLRVKITPRD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	148/474 (31%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	152/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460481
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000