DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	162/535 - (30%)
Similarity:	266/535 - (49%)	Gaps:	62/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVF----ANCFDLLG 65
            ||::.|.:|....||..:.:     |...|:|....| |:  ..|:|....:.    ...|..:|
  Fly     2 LLFLLVVLLFGAGWIIHLGQ-----ADRRRKVANLPG-PI--CPPLIGAMQLMLRLNPKTFIKVG 58

  Fly    66 KDTDQVFTHLR------QLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLH 124
            ::....|.||:      :|...|||:.|       |..::.:..  :::.||       :|..|.
  Fly    59 REYVLKFGHLQRVWIFNRLLIMSGDAEL-------NEQLLSSQE--HLVKHP-------VYKVLG 107

  Fly   125 PFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQF-QGQNEVVVSLKDRIS 188
            .:|..|:|.:..|.||.||.::|.|||..||.||.|:|..:|...|.:. |..|.....:...|.
  Fly   108 QWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSIC 172

  Fly   189 RFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMFTGH---KYNA 250
            ...|:.|.|||||.|:...|.:...|....:.....|:.|.::.....:.::.:...|   :...
  Fly   173 AAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQ 237

  Fly   251 ALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDG--LIDDI 313
            .::.:.||:.::|.|||..||:  :..:...|||:|  |..|:|.|:||.|:.:..||  |.:|
  Fly   238 LIRTMQEFTIKVIEKRRQALED--QQSKLMDTADED--VGSKRRMALLDVLLMSTVDGRPLTND- 297

  Fly   314 GISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSN-LNLSQLSKLNYL 377
            .|.|||||.|.||:|||:..|.|.|..:|.:...|....:||.:.:..|.|. :::..|.:|.|:
  Fly   298 EIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYM 362

  Fly   378 GYFIKETMRLYPSIPIMGRQTLQETELENGL----ILPKRSQINIHVFDIHRNPKYWESPEEFRP 438
            ...|||::|:||.:||:||:...:.:..:.:    ::|..|:|.|.:|.:||.|:.:.:|:||.|
  Fly   363 ECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIP 427

  Fly   439 ERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILP----------VIDP 493
            ||.  :|..:..|:..||||||.|||||||:|..|||.::..|::.:::||          ::..
  Fly   428 ERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVNIVLR 490

  Fly   494 KSIVFQVGITLRFKN 508
            ....||:|:..|..|
  Fly   491 SETGFQLGMRKRKHN 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	148/473 (31%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	142/453 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460523
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000