DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp316a1

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	121/509 - (23%)
Similarity:	207/509 - (40%)	Gaps:	128/509 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FFARRVQ--TKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQVFTHL----------RQLAKNSG 83
            ||.|..:  ||.|              .|:.|:         ||..|          |||.:|
  Fly    54 FFQRSTEYLTKYG--------------TFSRCW---------VFHRLFIPLADLELSRQLLEN-- 93

  Fly    84 DSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTR 148
            |::|:..                             |..:..:|..|||....::|..|.|:::.
  Fly    94 DTHLETG-----------------------------YELMKDWLVGGVLMCQSEQWQKRHSLISG 129

  Fly   149 TFHLDILNQFQEIFIAESLKFVSQFQGQ-NEVVVSLKDRISRFTLNSICETAMGIKLDE-----M 207
            .|....|.|..::...::.:.:.:...| ::.|..:...:|...|:.:..|..|.|..|     :
  Fly   130 LFDKGNLEQLIDLSRHQTEQLLQKLAKQADQKVFDIWYTVSPIVLDLMVMTTCGAKPSEEYSKNL 194

  Fly   208 AEKGDRYRANFHIIDEGLTRRIVNPL-YWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRVLLE 271
            .:..:.||..|      |:.:..|.. ||   :.:.|...:.|..:|.:::....::|..:...:
  Fly   195 KDLSEIYRKRF------LSLQSANRFNYW---LSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQNQ 250

  Fly   272 EELENRRATQTADDDICVIR----KKRFAMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTSI 332
            .::||..       ||..:|    |...::|:.|: ..||..:....|..|::|....||...|.
  Fly   251 LKIENGL-------DIYQLRPIPLKDHKSLLEILL-ESKDPQLTGEEICGELNTCNYLGYQLCSP 307

  Fly   333 GLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQ-------LSKLNYLGYFIKETMRLYPS 390
            .|.|.|:.::...:.|:.|           |..|||:|       |.|||||...:.|||||||.
  Fly   308 ALCFCLVTIARNPSVQQKC-----------LDELNLAQIKDQGWDLEKLNYLDAVLHETMRLYPP 361

  Fly   391 IPIMGRQTLQETELENGLI----LPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHP 451
            ..|:|||..::....:.::    ||..|:|.|:::::.||...:.....|..:|||..      |
  Fly   362 QVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDS------P 420

  Fly   452 YAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITLR 505
            ...:.:|.|.|.|..:|::||.:|||:..||.:|::||..|      :|.:.||
  Fly   421 PELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGD------EVRLDLR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	113/475 (24%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	119/505 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070