DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	554	Identity:	155/554 - (27%)
Similarity:	260/554 - (46%)	Gaps:	113/554 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MICLLWISVAILVV---------------IHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMI 51
            :.|||.: |.:|:|               .||::...|::.           :||..|:.:|..:
Zfish    22 LACLLTV-VKLLIVRRKGVKTMERFPGPPAHWLFGHVKEFR-----------QDGHDLEKIVKWM 74

  Fly    52 KGRTVFANCFDLLGKDTDQVFTHLRQLAKNSGDSYLQYSMGFS-NFNVIDAHNAANILNHPNLIT 115
            :                      |.|.|         :.:.|. :..|::.|       ||:.:
Zfish    75 E----------------------LYQFA---------FPLWFGPSLAVLNIH-------HPSYV- 100

  Fly   116 KGVI----------YNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFV 170
            |.::          |.|..|:|..|:|.:|.:||...|.:||..||.|:|..:.:: |::|.|.:
Zfish   101 KTILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKL-ISDSTKVM 164

  Fly   171 S---QFQGQNEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDR--YRANF---HIIDEGLTR 227
            .   :...::|....|...:|..||:||.:.|.....:...:.|..  .:|.|   |:::   .|
Zfish   165 LDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVN---LR 226

  Fly   228 RIVNPLYWDDCVYNMFT-GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIR 291
            ..|.| |....::::.. |:::..|..:.|..:.|:|.||:.:|:.|.|..           :::
Zfish   227 FRVFP-YHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQG-----------IVK 279

  Fly   292 KKRFA-MLDTLICA---EKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCY 352
            .:|:. .||.|:.|   .:.||.|: .|..||||.|.||:|||:.|:.:...|::.....||.|.
Zfish   280 NRRYLDFLDILLSARDEHQQGLSDE-DIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCR 343

  Fly   353 QEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQIN 417
            ||||: .||..:.|....|:|:.|....|||::||:|.:|.:.|:..:.....:|..:|:...|.
Zfish   344 QEIQQ-ALDGKATLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPLTFFDGRTVPEGCTIG 407

  Fly   418 IHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVIL 482
            :.::.||.|...||:|.:|.|.||||:|...|.|:|::|||||.||||||.:||.|||..:.:.|
Zfish   408 VSIYGIHMNSTVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTL 472

  Fly   483 KHFKIL--PVIDPKSIVFQVGITLRFKNKIKVKL 514
            |.:.::  |...||.|   ..:.||..|.|.:|:
Zfish   473 KRYYLIKDPDHTPKMI---PQVVLRSLNGIHIKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	141/476 (30%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	148/525 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850