DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	532	Identity:	124/532 - (23%)
Similarity:	230/532 - (43%)	Gaps:	103/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NCFDLLGKDTDQVF-----------THLRQLAKNSG----------DSYLQYSMGFSNFN----- 97
            |.|..|..||..:.           |....|.|..|          .:.|.|..|...|:
Mouse     2 NLFSALSLDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTGIWKFDMECYE 66

  Fly    98 -------VIDAHNAANILNHPNLITKGVIYNFLHPFLR------TGVLT-----ATEKKWHTRRS 144
                   :.|......::..|..|...::.:.|..|..      .|:::     :.:::|...|:
Mouse    67 KYGKTWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVGIMSKAISISKDEEWKRYRA 131

  Fly   145 MLTRTF-------HLDILNQFQEIFIAESLKFVSQFQGQNEVVVSLKDRISRFTLNSICETAMGI 202
            :|:.||       ...::.|:.:|.:    |::.| :.:..:.|::||.:..::::.|..|:.|:
Mouse   132 LLSPTFTSGRLKEMFPVIEQYGDILV----KYLRQ-EAEKGMPVAMKDVLGAYSMDVITSTSFGV 191

  Fly   203 KLDEMAEKGDRY--------RANFHIIDEGLTRRIVNPLYWDDCVYNMFTGHKY-NAALKVVHEF 258
            .:|.:....|.:        |.:|  .|..|...::.||...  ||.|.....: |.::    ||
Mouse   192 NVDSLNNPEDPFVEEAKKFLRVDF--FDPLLFSVVLFPLLTP--VYEMLNICMFPNDSI----EF 248

  Fly   259 SREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLI-----CAEKDG--LIDDIGIS 316
            .::.:.:   :.|..|::.             :|.|...|..::     ..:||.  ...::.|:
Mouse   249 FKKFVDR---MQESRLDSN-------------QKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEIT 297

  Fly   317 EEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFI 381
            .:....::.||:|||..|.|.|..::.:...|:....|| :..|.:.:......:.::.||...:
Mouse   298 VQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEI-DKALPNKATPTCDTVMEMEYLDMVL 361

  Fly   382 KETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNC 446
            .||:||||.:..:.|...::.|| ||:.:||.|.:.|..:.:|.:|::|..||||:||||..:|.
Mouse   362 NETLRLYPIVTRLERVCKKDVEL-NGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENK 425

  Fly   447 LKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVID---PKSIVFQVGITLRFKN 508
            ....||.|:||..|.|||||.::|:..||..:..:|::|...|..:   |..:..| || |:.:.
Mouse   426 GSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQ-GI-LQPEK 488

  Fly   509 KIKVKLVRRNCV 520
            .|.:|:|.|:.|
Mouse   489 PIVLKVVPRDAV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	118/520 (23%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	111/487 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910