DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	157/525 - (29%)
Similarity:	260/525 - (49%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SVAILVVIHWIYKVNKDYNILAF--FARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQV 71
            ::|::..:.|...:.....||.|  ..|..:|..|..:..|:..:|               ..::
  Fly     3 TLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVK---------------KGEI 52

  Fly    72 FTHLRQLAKNSGDSYLQYSMGFSNFNVI---DAHNAANILNHPNLITKGVIYNFLHPFLRTGVLT 133
            ...|::|.:..|.   .:.:.|....::   |..:...:|.:..|:||...|..|.|:|..|:||
  Fly    53 LNWLKELREKHGP---VFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLT 114

  Fly   134 ATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQ-NEVVVSLKDRISRFTLNSICE 197
            ...:.||.||.:||..||..||::|:|.........|.:.:.: |.....:...|:.|.|::|||
  Fly   115 NGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICE 179

  Fly   198 TAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMF-----TGHKYNAALKVVHE 257
            ||||||.....:....|......|...:.::..:  :|..  .|:|     .|.:..|||||:|:
  Fly   180 TAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFS--FWQR--LNVFFKHTKPGKEREAALKVLHD 240

  Fly   258 FSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDG--LIDDIGISEEVD 320
            .:..:|..||..|.:| .|....:...||:..  |:|.|.||.|:..:.:|  .:.|..|.||||
  Fly   241 ETNRVIRLRREQLIQE-RNEWKPEAEQDDVGA--KRRLAFLDMLLLTQMEGGAELSDTDIREEVD 302

  Fly   321 TLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETM 385
            |.|.||:||||..:.|.|..:|.        ..::|:...::.|.|...:...:.||...||||:
  Fly   303 TFMFEGHDTTSSAIAFALSLLSK--------NPDVQQRAFEEASELEGREKESMPYLEAVIKETL 359

  Fly   386 RLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRH 450
            |:|||:|...|:.|::.|: ..|.:||.:.|:..::.:||:||.:..||.|.|:||| .|..:.|
  Fly   360 RIYPSVPFFSRKVLEDLEV-GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMH 422

  Fly   451 PYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVID--PKSIVFQVGITLRFKNKIKVK 513
            |:|:..||||.|||||||:||.|:||.:.::|:.::.||..|  ||.:   ..:..:..|.|:::
  Fly   423 PFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPL---AELVTKSGNGIRLR 484

  Fly   514 LVRRN 518
            ::.|:
  Fly   485 ILPRD 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	146/463 (32%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	146/468 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460487
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000