DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	161/469 - (34%)
Similarity:	259/469 - (55%)	Gaps:	32/469 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GKDTDQVFTHLRQLAKNSGDSY----LQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHP 125
            |.|.:|:...:::..:..|..|    |.....||.    |..:...:|:....|||..:|..|:.
  Fly    48 GLDPEQIMDFVKKNQRKYGRLYRVWILHQLAVFST----DPRDIEFVLSSQQHITKNNLYKLLNC 108

  Fly   126 FLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQNE--VVVSLKDRIS 188
            :|..|:|.:|.:|||.||.::|.|||..||.||.|||..:|...|.|.|.:.:  ..:::...|.
  Fly   109 WLGDGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVIC 173

  Fly   189 RFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNM---FTGHKYNA 250
            ...|:.|.|||||.|::........|....:.:...|.:|.::.....|.::.:   ....:.:.
  Fly   174 LTALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDK 238

  Fly   251 ALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVI-RKKRFAMLDTLICAEKDGL-IDDI 313
            |:||:|:|:..||.:||    |.|.|.....|.::::..: :|:|.|:||.|:.:..||. :.|.
  Fly   239 AIKVMHDFTENIIRERR----ETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDE 299

  Fly   314 GISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDD-LSNLNLSQLSKLNYL 377
            .|.|||||.|.||:|||:..:.|.|..:|.:...|:...|||::.:.:| .|.:.|..|.:|.::
  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364

  Fly   378 GYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERF- 441
            ...|||::||:|.:|::||...::.|: .|..:|..:...:.:|.:.|:|:|:|||:|||||||
  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD 428

  Fly   442 --LPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPV-IDPKSIVFQVGIT 503
              :||    .|||||||||||.|||||||:||.|||:.:..:|:||::||: .:|:   ..:.|.
  Fly   429 ADVPQ----IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPR---HSMNIV 486

  Fly   504 LRFKNKIKVKLVRR 517
            ||..|.:.:.|..|
  Fly   487 LRSANGVHLGLKPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	159/464 (34%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	159/462 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460499
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000