DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	162/495 - (32%)
Similarity:	259/495 - (52%)	Gaps:	53/495 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GKPLDSLVPMIKGRTVFANCFDLLGK-DTDQVF-----THLRQLAKNSGDSYLQYSMGFSNFNVI 99
            |||...:|..|         |:.:.. ..|||.     ..|..|..|..|  ::..:|...||
  Fly    51 GKPPHEMVKKI---------FEFMETYSKDQVLKVWLGPELNVLMGNPKD--VEVVLGTLRFN-- 102

  Fly   100 DAHNAANILNHPNLITKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIA 164
                           .|...|..|.|:|:.|:|.:..:|||.||.::|..||..||:||.|:|..
  Fly   103 ---------------DKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEK 152

  Fly   165 ESLKFVSQFQ----GQNEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGL 225
            .|...:...:    ...:...||.|.|:..|:::|||||||:.::..:.....|......|...|
  Fly   153 GSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVL 217

  Fly   226 TRRIVNPLYWDDCVYNMFT--GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDIC 288
            .:|:.|.||..|..| |.|  ......||.|:|:|:.:||.:||   ||.:....:.::::||..
  Fly   218 HKRMFNILYRFDLTY-MLTPLARAEKKALNVLHQFTEKIIVQRR---EELIREGSSQESSNDDAD 278

  Fly   289 VIRKKRFAMLDTLICAEKDGL-IDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCY 352
            |..|::.|.||.|:.:..|.. :.::.|.|||||.|.||:||||..|:|...|::.:...|:.|:
  Fly   279 VGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCF 343

  Fly   353 QEIQEHILDDLSN-LNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQI 416
            :||:..:.:|.|. ::...|::|:|:...:|||:|:|||:|::||:.|::.|: ||.::|..:.|
  Fly   344 EEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNI 407

  Fly   417 NIHVFDIHRNPKYWESPEEFRPERF-LPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVV 480
            .|....:.|..:.:..|..|:|||| :.....|.:||||||||||.|||||||:||.|:|.::..
  Fly   408 GISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVAN 472

  Fly   481 ILKHFKILPVID---PKSIVFQVGITLRFKNKIKVKLVRR 517
            :|:|:::..|.|   |..::.:  :.||.|..:..|:..|
  Fly   473 VLRHYEVDFVGDSSEPPVLIAE--LILRTKEPLMFKVRER 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	154/468 (33%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	160/490 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460511
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.000