DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	559	Identity:	178/559 - (31%)
Similarity:	269/559 - (48%)	Gaps:	96/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLWISVAIL------VVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDL 63
            |||.:.:.|      :|:..:.:|       |.:||:.|..  :|:.::          |..:.|
Human    14 LLWGAASALSLAGASLVLSLLQRV-------ASYARKWQQM--RPIPTV----------ARAYPL 59

  Fly    64 LGKDTDQVFTHLRQLAKNSGDSYLQ----YSMGFSNFNVI-------------DAHNAANILNHP 111
            :|.         ..|.|..|..:.|    |:..:.:..::             :|.|...||...
Human    60 VGH---------ALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSS 115

  Fly   112 NLITKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQ 176
            ..|.|..:|.||.|:|..|:||:|..||.:||.|||.|||..||..|.:|...::...|.:.:..
Human   116 KQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 180

  Fly   177 -NEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVY 240
             |:...:....|:...|:.|||||||..:...:.....|....:.:.|.:.|||..|..|.|..|
Human   181 INQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWY 245

  Fly   241 NMF-TGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDIC--------VIRKKRFA 296
            .|| .|.::..:|:::|.|:..:||:            ||.:...::.|        ..:.||.|
Human   246 LMFKEGWEHKKSLQILHTFTNSVIAE------------RANEMNANEDCRGDGRGSAPSKNKRRA 298

  Fly   297 MLDTLICAEKDGLIDDIG-------ISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQE 354
            .||.|:     .:.||.|       |.|||||.|.||:|||:..:     |.|||........|:
Human   299 FLDLLL-----SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAI-----NWSLYLLGSNPEVQK 353

  Fly   355 IQEHILDDLSN-----LNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRS 414
            ..:|.|||:..     ..:..|.||.||...||||:||:||:|:..|...::.|:....:| |.:
Human   354 KVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGT 417

  Fly   415 QINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMV 479
            :..|..:.:||:|:|:.:||||:||||.|:|...||||||:|||||.|||||||:|:.|.||::.
Human   418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILS 482

  Fly   480 VILKHFKILPVIDPKSIVFQVGITLRFKNKIKVKLVRRN 518
            .||:||.|......:.:..:..:.||..|.|.:||.|||
Human   483 CILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	161/489 (33%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	161/493 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950