Protein Alignment Cyp4p2 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 119/409 - (29%)
• Similarity: 215/409 - (52%)
• Gaps: 32/409 - (7%)

  Fly   120 YNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFV----SQFQGQNEVV 180
            |.||.|.:..|:|....:.|...|.|||..||.|||..:..: :|:|::.:    .:..||:. .
Human   120 YKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGL-MADSVRVMLDKWEELLGQDS-P 182

  Fly   181 VSLKDRISRFTLNSICETAM----GIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYN 241
            :.:...:|..||::|.::|.    .|::|..::.   |......::..:...:.|..:.:|.:|:
Human   183 LEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQS---YIQAISDLNSLVFCCMRNAFHENDTIYS 244

  Fly   242 MFTGHKY-NAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICA- 304
            :.:..:: :.|.::.|:.:.::|..|:..|::|.|..:          :.||:....||.|:.|
Human   245 LTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK----------IKRKRHLDFLDILLLAK 299

  Fly   305 -EKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNL 368
             |...::.|..:..||||.|.||:|||:.|:.:.|..::.:...||.|.:|| ..:|.|.:::..
Human   300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEI-HGLLGDGASITW 363

  Fly   369 SQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESP 433
            :.|.::.|....|||.:||||.:|.:||:........:|..|||...:.:.::.:|.|||.|.:.
Human   364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428

  Fly   434 EEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVF 498
            |.|.|.||.|.:.  :|.:|::|||.|.|||||:::||.::|....:.|..|::||  ||..|..
Human   429 EVFDPSRFAPGSA--QHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP--DPTRIPI 489

  Fly   499 QVG-ITLRFKNKIKVKLVR 516
            .:. :.|:.||.|.::|.|
Human   490 PMARLVLKSKNGIHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	117/403 (29%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	117/404 (29%)