DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4p2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	177/555 - (31%)
Similarity:	268/555 - (48%)	Gaps:	88/555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLW-----ISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLL 64
            |||     :|||...|:..|.:      :|..:||:.|..  :|:.|:          |..:.|:
  Rat    14 LLWGAASAVSVAGATVLLNILQ------MLVSYARKWQQM--RPIPSV----------ARAYPLV 60

  Fly    65 GKDTDQVFTHLRQLAKNSGDSY---LQYSMGFSNFNVI-------------DAHNAANILNHPNL 113
            |        |...:..|:.:.:   :||:..|.:..:|             .|.|...||.....
  Rat    61 G--------HALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQ 117

  Fly   114 ITKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQGQ-N 177
            |.|..:|.||.|:|..|:||:|..||..||.|||.:||..||..|.::...::...|::.:.. |
  Rat   118 IDKSFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVN 182

  Fly   178 EVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNM 242
            :...:....|:...|:.|||||||..:...:.....|....:.:.:.:.||:..|.:|.|..|.|
  Rat   183 QEAFNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLM 247

  Fly   243 F-TGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICV--------IRKKRFAML 298
            | .|..:...||.:|.|:..:||:|       :..|:|.|.     |:        .:.||.|.|
  Rat   248 FKEGRDHKKGLKSLHTFTNNVIAER-------VNARKAEQD-----CIGAGRGPLPSKTKRKAFL 300

  Fly   299 DTLICA--EKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHI-- 359
            |.|:..  |:...:....|.|||||.|.||:|||:..:     |.|||.....   .|:|..:
  Rat   301 DLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAI-----NWSLYLLGSN---PEVQRKVDK 357

  Fly   360 -LDDLSN-----LNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINI 418
             |||:..     :.|..|.||.||...||||:|::||:|:..|...::.|:. |..:.|.::..|
  Rat   358 ELDDVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVA-GYKISKGTEAVI 421

  Fly   419 HVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILK 483
            ..:.:||:|:|:..||||:||||.|:|...||||||:|||||.|||||||:|:.|.||::..||:
  Rat   422 IPYALHRDPRYFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILR 486

  Fly   484 HFKILPVIDPKSIVFQVGITLRFKNKIKVKLVRRN 518
            .|.|......:.:.....:.||..|.|.:||.||:
  Rat   487 EFWIESNQKREELGLAGDLILRPNNGIWIKLKRRH 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	158/486 (33%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	154/459 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950