Protein Alignment Cyp4p2 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 123/555 - (22%)
• Similarity: 235/555 - (42%)
• Gaps: 112/555 - (20%)

  Fly     7 WISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQV 71
            |:.:|..:::.:||         ..::..:..|.|.|....||:.  .|:| |..|.:.|..|
  Rat    12 WVLLATSLMLFYIY---------GTYSHGLFKKLGIPGPKPVPLF--GTIF-NYGDGMWKFDD-- 62

  Fly    72 FTHLRQLAKNSGDSYLQYS--MGFSN-----FNVIDAHNAANILNHPNLITKGVIYNFLHP---- 125
                        |.|.:|.  .||..     ..::|          |.:| |.|:....:.
  Rat    63 ------------DCYKKYGKIWGFYEGPQPFLAIMD----------PEII-KMVLVKECYSVFTN 104

  Fly   126 --------FLRTGVLTATEKKWHTRRSMLTRTF-------HLDILNQFQEIFIAESLKFVSQFQG 175
                    |::..:..:.:::|...|::|:.||       ...::.|:.:..    ||.:.:.:.
  Rat   105 RRCFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTL----LKNLRREEA 165

  Fly   176 QNEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRY--RA----NFHIIDEGLTRRI----V 230
            :.| .:::||....::::.|..|:.|:.:|.:....|.:  :|    .|.|.|..|...:    :
  Rat   166 KGE-PINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFL 229

  Fly   231 NPLYWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRF 295
            .|:| :...:::|.....|...|.|....:..:...:....:.|:....||.:...
  Rat   230 TPIY-EMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQ--------- 284

  Fly   296 AMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHIL 360
                     |....:.|:.::.:....:..|||.||..:.|.:..::.....|:....|| :..|
  Rat   285 ---------ESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEI-DRAL 339

  Fly   361 DDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHR 425
            .:.:.:....|.::.||...:.|::||||....:.|.:.::.|: ||:.:||.:.:.|.::.:||
  Rat   340 PNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEI-NGVFIPKGTVVTIPIYPLHR 403

  Fly   426 NPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKI--- 487
            ||:||..||||.||||..:|.....||.|:||..|.|||||.::|:..||..::.:|::|.|
  Rat   404 NPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPC 468

  Fly   488 ----LPVIDPKSIVFQVGITLRFKNKIKVKLVRRN 518
                :|:...:..:||.      :..|.:|||.|:
  Rat   469 EKTQIPLKISRQPIFQP------EGPIILKLVSRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	104/471 (22%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	102/467 (22%)