DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	160/540 - (29%)
Similarity:	256/540 - (47%)	Gaps:	83/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQ 70
            ||.||.||:||     |.|.:::|....:..:..|..|                     |..|..
  Rat    15 LWASVVILMVI-----VLKLFSLLLRRQKLARAMDSFP---------------------GPPTHW 53

  Fly    71 VFTHLRQLAK-NSGDSYLQYS--------------MGFSNFNVIDAHNAANILNHPNLITKGVIY 120
            :|.|..::.| .|.|..:.::              :||.|....|...|......|....   :|
  Rat    54 LFGHALEIQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAAD---VY 115

  Fly   121 NFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFV----SQFQGQNEVVV 181
            :|...::..|:|.....||...|.:||..||.|:|..:..|| |||.:.:    .:...:|:...
  Rat   116 DFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIF-AESTRMMLDKWEKKASENKSFD 179

  Fly   182 SLKDRISRFTLNSICETAMGIKLDEMAEKGDR---YRAN-FHIIDEGLT----RRIVNPLYWDDC 238
            ...| :....|:::.:...|        |||.   :|.| :::....||    :||.:..|.:|.
  Rat   180 IFCD-VGHMALDTLMKCTFG--------KGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDF 235

  Fly   239 VYNMFT-GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLI 302
            :|.:.. |.::..|.|:.|:.:.|:|.:|:..|::|.|.::..|          ::....||.|:
  Rat   236 IYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQ----------RRHLDFLDILL 290

  Fly   303 -CAEKDGL-IDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSN 365
             ..::.|: :.|..:..||||.|.||:|||:.|:.:.|..|:||...|:||.:|:: .||.|..:
  Rat   291 GVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVR-GILGDQDS 354

  Fly   366 LNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYW 430
            .....|:|:.||...:||..||||.:|.:.||..:.....:|..||..|.|::|::.:|||...|
  Rat   355 FQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVW 419

  Fly   431 ESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKS 495
            ..||.|.|.||.|:|...|||:|::|||||.||||||::||.|||.:..:.|..|:.  .:||..
  Rat   420 PDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF--SLDPSK 482

  Fly   496 IVFQV-GITLRFKNKIKVKL 514
            :..:| .:.||.||.|.:.|
  Rat   483 MPIKVPQLILRSKNGIHLYL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	146/481 (30%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	147/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850