Protein Alignment Cyp4p2 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 150/551 - (27%)
• Similarity: 245/551 - (44%)
• Gaps: 105/551 - (19%)

  Fly     1 MMICLLWISVAILVVI---------------------HWIYKVNKDYNILAFFARRVQTKDGKPL 44
            :::.||.:|:.:..||                     ||.|...:.|.:..|   .|..|..:..
Human    15 LLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEF---EVYHKLMEKY 76

  Fly    45 DSLVPMIKGR-TVFANCFDLLGKDTDQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANIL 108
            ...||:..|. |:|                                      |:|.|...|..:|
Human    77 PCAVPLWVGPFTMF--------------------------------------FSVHDPDYAKILL 103

  Fly   109 NHPNLITKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFI---AESLKFV 170
            ...: ....|.:..|..::..|::|....||...|.::...|::.||    :|||   :||::.:
Human   104 KRQD-PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISIL----KIFITMMSESVRMM 163

  Fly   171 ----SQFQGQNEVVVSLKDRISRFTLNSICETAM----GIKLDEMAEKGDRYRANFHIIDEGLTR 227
                .:...||. .:.|...:|..||:||.:.|.    .|:||...   |.|......:.:...:
Human   164 LNKWEEHIAQNS-RLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTL---DSYLKAVFNLSKISNQ 224

  Fly   228 RIVNPLYWDDCVYNMFT-GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIR 291
            |:.|.|:.:|.|:...: |..::...:.:|:|:.::|..|:..|:::|: :..||
Human   225 RMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLK-QDTTQ---------- 278

  Fly   292 KKRFAMLDTLICAEKDGLID--DIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQE 354
            |:|:..||.|:.|:.:...|  :..:..||.|.|..|:||||..:.:.|..::.|...|:.|..|
Human   279 KRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDE 343

  Fly   355 IQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIH 419
            |:| :|.|.|::....||::.|....|||.:|||..:..:.|...:.....:|..||....:.|:
Human   344 IRE-LLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFIN 407

  Fly   420 VFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKH 484
            ::.:|.||.:||.|:.|.|.||..:|..|.||||:||||||.||||||.:|:.|.|..:.:.|..
Human   408 IWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLR 472

  Fly   485 FKILPVID---PKSIVFQVGITLRFKNKIKV 512
            ||:.|  |   |...|.||  .|:.||.|.|
Human   473 FKLAP--DHSRPPQPVRQV--VLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	132/445 (30%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	141/500 (28%)