DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and cyp-35D1

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_507044.1	Gene:	cyp-35D1 / 184495	WormBaseID:	WBGene00008829	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	113/550 - (20%)
Similarity:	190/550 - (34%)	Gaps:	147/550 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MICLLWISVAILVVIHWIYKVNKDYNILAF---------------FARRVQTKDGKPLDSLVPMI 51
            ||.:|....||.|:...:|:     .:|.|               .|.:...:.|     ::|.:
Worm     1 MILILLFLTAITVITVRLYR-----KVLRFPPGPFPLPLIGNAHQIAYQAWRRGG-----ILPAL 55

  Fly    52 K-GRTVFANCFDL-LGKDTDQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLI 114
            . .|..:.|.:.| ||.......|..    :.|.:.:::  .|...:|    ...|.||.|   :
Worm    56 DYYRKKYGNAYTLWLGPKASVSITDF----ETSQEVFVK--QGKKCYN----RQLAPILEH---V 107

  Fly   115 TKGVIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFH-------------LDILNQFQEIFIAES 166
            |.||           |:|.|..:.|...|.....||.             :|.||       ...
Worm   108 TGGV-----------GLLIANGENWAEMRRFTLLTFRQMGVGTNIMEKRIMDELN-------GRC 154

  Fly   167 LKFVSQFQGQNEVVVSLK--DRISRFTLNSIC--------ETAMGIK--LDEMAEKGDRYRANFH 219
            |:..:|....:..:|.:|  |......:||..        |..:.||  .||.:|       .|:
Worm   155 LEIDAQIARNDRAIVDVKFFDLTVGSVINSFLIGKRFEDEEEFLKIKKLFDESSE-------TFN 212

  Fly   220 IIDEG---------LTRRIVNPLYWDDCVYNMFTGHK-YNAALKVVHEFSREIIAKRRVLLEEEL 274
            |.|..         |..|.  .|.||       :.|: .:..:|.|.|..|:|.:.     ..::
Worm   213 IFDLNVPVWFLKTFLPSRF--KLTWD-------SRHQIMDHVMKGVEERIRDIESG-----AYKI 263

  Fly   275 ENRRATQTADDDICVIRKKR--------FAMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTS 331
            :.::.....|..:..::|:.        :..|.:|.....|              |...|..||:
Worm   264 DPKKPNDVVDAFLSKMKKEEEIAGGQHPYYNLKSLKLVLHD--------------LWLAGQGTTA 314

  Fly   332 IGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSN----LNLSQLSKLNYLGYFIKETMRLYPSIP 392
            ..|..|.|.:..:..    ..|.||:.:||...|    |.|.......||...|.|..|....:.
Worm   315 TTLYVGFMKLVNHPG----IIQNIQKELLDITENGARDLTLKDRPNTPYLNATIAEIQRHASILN 375

  Fly   393 IMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPF 457
            :...:...||...|...:...:.|...|..:|.|.:.:::|::|..|::|....|.:.   .|||
Worm   376 VNFWRINHETIHFNDYQVDPGTMIAAQVGVLHVNEELFDNPKDFNVEKYLKNPKLLQQ---VIPF 437

  Fly   458 SAGQRNCIGQKYAMQEMKTLMVVILKHFKI 487
            ..|:|:|:|::.|..|:..:...||..:.:
Worm   438 GIGKRSCVGEQIAKSELYLVFGNILLRYNV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	99/472 (21%)
cyp-35D1	NP_507044.1	p450	35..496	CDD:299894	104/510 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010