Protein Alignment Cyp4p2 and CYP19A1

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 113/438 - (25%)
• Similarity: 193/438 - (44%)
• Gaps: 99/438 - (22%)

  Fly    82 SGDSYLQYSMGFSNFNVIDAHNAANI-------LNHPNLITKGVIYNFLHPFLRTGVLTATEKKW 139
            ||:..|..|...|.|::: .||..:.       |....:..||:|:| .:|.|           |
Human    90 SGEETLIISKSSSMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGIIFN-NNPEL-----------W 141

  Fly   140 HTRRSMLTRTFHLDILN---QFQEIFI-AESLKF-------VSQFQGQNEVVVSLKDRISRFTLN 193
            .|     ||.|.:..|:   ..:.:.: |||||.       |:...|..:|:..|: |:...|.|
Human   142 KT-----TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR-RVMLDTSN 200

  Fly   194 SICETAMGIKLDEMA----EKG--DRYRANFHIIDEGLTRRIVNP-----LYWDDCVYNMFTGHK 247
            ::   .:.|.|||.|    .:|  |.::|           .::.|     :.|   :|.     |
Human   201 TL---FLRIPLDESAIVVKIQGYFDAWQA-----------LLIKPDIFFKISW---LYK-----K 243

  Fly   248 YNAALKVVHEFSREIIA--KRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDGLI 310
            |..::|.:.:....:||  :||:..||:||.           |:    .||  ..||.|||.|.:
Human   244 YEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-----------CM----DFA--TELILAEKRGDL 291

  Fly   311 DDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLN 375
            ....:::.:..::....||.|:.|.|.|..::.:...:|...:|||..|.:  .::.:..:.||.
Human   292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKIDDIQKLK 354

  Fly   376 YLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPER 440
            .:..||.|:||..|.:.::.|:.| |.::.:|..:.|.:.|.:::..:|| .:::..|.||..|.
Human   355 VMENFIYESMRYQPVVDLVMRKAL-EDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLEN 417

  Fly   441 FLPQNCLKRHPYAYI-PFSAGQRNCIGQKYAMQEMKTLMVVILKHFKI 487
            |     .|..||.|. ||..|.|.|.|:..||..||.::|.:|:.|.:
Human   418 F-----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	112/437 (26%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	113/438 (26%)