Protein Alignment Cyp4p2 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 112/501 - (22%)
• Similarity: 215/501 - (42%)
• Gaps: 85/501 - (16%)

  Fly    73 THLRQLAKNSG----------DSYLQYSMGFSNFNV------------IDAHNAANILNHPNLIT 115
            ||...|.|..|          .:.|.|..||..|::            .|.......:..|::|
Human    27 THSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMI- 90

  Fly   116 KGV-------IYNFLHP-----FLRTGVLTATEKKWHTRRSMLTRTF-------HLDILNQFQEI 161
            |.|       ::....|     |:::.:..|.:::|...||:|:.||       .:.|:.|:.::
Human    91 KTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155

  Fly   162 FIAESLKFVSQFQGQNEVVVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRAN------FHI 220
            .:....:     :.:....|:|||....::::.|..|:.|:.:|.:....|.:..|      |..
Human   156 LVRNLRR-----EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 215

  Fly   221 IDEGLTRRIVNPL------YWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRV-LLEEELENRR 278
            :|.......|.|.      ..:.||:.....:....::|.:.|...|...|.|| .|:..::::.
Human   216 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280

  Fly   279 ATQTADDDICVIRKKRFAMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSL 343
            :.:|                      |....:.|:.:..:....:..||:|||..|.|.:..::.
Human   281 SKET----------------------ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323

  Fly   344 YAAEQELCYQEIQEHILDDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGL 408
            :...|:...:|| :.:|.:.:......:.::.||...:.||:||:|....:.|...::.|: ||:
Human   324 HPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGM 386

  Fly   409 ILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQE 473
            .:||...:.|..:.:||:||||..||:|.||||..:|.....||.|.||.:|.|||||.::|:..
Human   387 FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMN 451

  Fly   474 MKTLMVVILKHFKILPVIDPK-SIVFQVGITLRFKNKIKVKLVRRN 518
            ||..::.:|::|...|..:.: .:...:|..|:.:..:.:|:..|:
Human   452 MKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	110/495 (22%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	105/483 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910