Protein Alignment Cyp4p2 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 119/533 - (22%)
• Similarity: 231/533 - (43%)
• Gaps: 98/533 - (18%)

  Fly     7 WISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFAN---CFDLLGKDT 68
            |:.:|:.:::.::|...         ...:..|.|.|..:.:|.:.....|..   .||:
Human    12 WLLLAVSLILLYLYGTR---------THGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDM----- 62

  Fly    69 DQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGV-------IYNFLHP- 125
                           :.|.:|.   ..:.:.|.......:..|::| |.|       ::....|
Human    63 ---------------ECYKKYR---KVWGIYDCQQPMLAITDPDMI-KTVLVKECYSVFTNRRPF 108

  Fly   126 ----FLRTGVLTATEKKWHTRRSMLTRTF-------HLDILNQFQEIFIAESLKFVSQFQGQNEV 179
                |::..:..|.:::|...||:|:.||       .:.|:.|:.::.:....:     :.:...
Human   109 GPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRR-----EAETGK 168

  Fly   180 VVSLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIV--NPLYWDDCVYNM 242
            .|:||.....::::.|..|:.|:.:|.:....|.:..|        |::::  |||  |..|.::
Human   169 PVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVEN--------TKKLLRFNPL--DPFVLSI 223

  Fly   243 FTGHKYNAALKVVH--EFSREIIAKRRVLLEEELENR-RATQTADDDICVIRKKRFAMLDTLICA 304
            .........|:.::  .|.|::|:.....:::..|.| :.||          |.|...|..:|.:
Human   224 KVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQ----------KHRVDFLQLMIDS 278

  Fly   305 E--KDG----LIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDL 363
            :  ||.    .:.|:.:..:....:..||:|||..|.|.:..::.:...|:...:|| :.:|.:.
Human   279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNK 342

  Fly   364 SNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPK 428
            :......:.:|.||...:.||:||:|....:.|...::.|: ||:.:||...:.|..:.:|.:||
Human   343 APPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPK 406

  Fly   429 YWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDP 493
            ||..||:|.||||..:|.....||.|.||.:|.|||||.::|:..||..:|.:|::|...|..:.
Human   407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471

  Fly   494 KSIVFQVGITLRF 506
                 |:.:.|||
Human   472 -----QIPLKLRF 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	109/454 (24%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	108/449 (24%)