Protein Alignment Cyp4p2 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 150/503 - (29%)
• Similarity: 238/503 - (47%)
• Gaps: 58/503 - (11%)

  Fly     7 WISVAILVVIHWIYKVNKDYNILAFF--ARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTD 69
            |:...||.   |.|         ||:  .||::         ..|..:.:..|.....|: ..|:
Human    29 WLLARILA---WTY---------AFYHNGRRLR---------CFPQPRKQNWFLGHLGLV-TPTE 71

  Fly    70 QVFTHLRQLAKNSGDSYLQYSMGFSNF--------NVIDAHNAANILNHPNLITKG--VIYNFLH 124
            :....|.||...       |..||..:        |:.......:::|..:.||..  |.|..|.
Human    72 EGLRVLTQLVAT-------YPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLK 129

  Fly   125 PFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQG---QNEVVVSLKDR 186
            |:|..|:|.:...||...|.:||..||.:||..:.:||...:....:::|.   :....:.:.:.
Human   130 PWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEH 194

  Fly   187 ISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVYNMF-TGHKYNA 250
            ||..||:|:.:...... ....||...|......:...:.:|......:.|.:|.:. .|.:::.
Human   195 ISLMTLDSLQKCIFSFD-SNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHR 258

  Fly   251 ALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDI-CVIRKKRFAMLDTLICAE-KDGL-IDD 312
            |.::||:|:..:|.:||..|        .:|..||.: ...:.|....:|.|:.:| |:|. :.|
Human   259 ACRLVHDFTDAVIQERRRTL--------TSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSD 315

  Fly   313 IGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILD-DLSNLNLSQLSKLNY 376
            ..|..|.||.|..|:|||:.||.:.|.|::.:...||.|.||:||.:.| :...:....|::|.:
Human   316 EDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380

  Fly   377 LGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERF 441
            |...:||::||:|.||...|...|:..|.:..::||.:..||::|.||.||..|..||.:.|.||
Human   381 LTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRF 445

  Fly   442 LPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILP 489
            .|:|..||.|.|:||||||.|||||||:||.|||.::.:.|..|:|||
Human   446 DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	CYP4	83..512	CDD:410721	134/425 (32%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	137/436 (31%)