DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4p2 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	437	Identity:	130/437 - (29%)
Similarity:	217/437 - (49%)	Gaps:	53/437 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LNHP----NLITKG--------VIYNFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQE 160
            |.||    :|:|..        :.|.|:.|:|...:|..:.::|...|.:||..||.|||.::..
Zfish    86 LFHPDYIRSLLTASASITLKDRIFYGFMKPWLGNCLLLQSGQEWSRHRRLLTPAFHFDILKKYVH 150

  Fly   161 IFIAESLKFVSQFQ---GQNEVVVSLKDRISRFTLNSI------CETAMGIKLDEMAEKGDRYRA 216
            ||...:.....:::   .:.|..|.:.::||..||:|:      |:|       ...||..:|.:
Zfish   151 IFNQSTNIMHDEWRRLLAKGEHSVDMFEQISSLTLDSLLKCTFSCDT-------HSQEKPRQYIS 208

  Fly   217 NFHIIDEGLTRRIVN-----PLYWDDCVYNMFTGHKYNAALKVVHEFSREIIAKRRVLLEEELEN 276
              .|:|  |:|.:|.     |.:||...:....|.::..|..|||:|:.:|:.:||..|:::.:
Zfish   209 --AILD--LSRLLVQRQHYLPYHWDWLYWRSAQGRRFQQACAVVHQFTADIVQERRTQLDQQSD- 268

  Fly   277 RRATQTADDDICVIRK-KRFAMLDTLICAEKD---GLIDDIGISEEVDTLMAEGYDTTSIGLVFG 337
               .::..::....|| |...::|.|:.|:.|   ||.:: .|....|..|..|:|||:..|.:.
Zfish   269 ---PESHPENTGRYRKRKNTDLIDLLLLAKDDKGEGLTNE-EIKAHADMFMFAGHDTTASALSWI 329

  Fly   338 LMNMSLYAAEQELCYQEIQEHILD-DLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQE 401
            ..|:::....||.|..|:::.:.| |...:....||:|.:....|||::||:..:..:.|...|.
Zfish   330 FYNLAMNQDYQERCRAEVRDLLADRDTHTIGWEDLSQLTFTTMCIKESLRLHSPVLALTRYYSQN 394

  Fly   402 TELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCIG 466
            .:.....::|......|.::.:||||:.|..|..|.|.||.|.|...|.|:|:||||||.|||||
Zfish   395 MKTPGDCVIPHGCLCLISIYGVHRNPQVWPDPLVFDPTRFDPHNSDSRSPHAFIPFSAGPRNCIG 459

  Fly   467 QKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQV------GITLRFK 507
            |.:||.|||.::.:.|..|||||...|...::|:      |:.|.|:
Zfish   460 QNFAMAEMKVVVALTLARFKILPGPKPVRRLYQLVLRAEGGMILHFQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	130/437 (30%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	128/432 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2076
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040